Laura: Hello and welcome to Lexx Education, the comedy science podcast, where comedian me, Laura Lexx, tries to learn science from her knocking over the microphone himself.
Laura: That it was nookie, but it was Ron.
Laura: It's Ron.
Laura: Hello, brother Ron.
Ron: I'm not Laura.
Laura: He's not Laura.
Laura: That's me, the one and only.
Ron: I am Laura Le, comedian actor.
Laura: This episode features my absolutely most tangential song cram in.
Laura: And if listeners spot it, I love them 1 million, because there's literally one word that is a very common word, and I interrupt you to sing as.
Ron: This the episode where I compliment you for just having something in the bank.
Laura: No matter what I say it is.
Laura: Yeah.
Laura: And then I really pull one out that just you can't do.
Laura: It would be like breaking into song every time someone said and it's kind of amazing to listen back to and hate myself for.
Laura: Are you feeling better about the podcast this week, Ron?
Ron: I am.
Ron: And I want to apologise to not only the listenership for my, let's say, overwhelming negativity on the last episode.
Ron: And also I want to make a personal apology to you, Laura, because I ate breakfast after we did that episode and I feel so much better about.
Laura: Life, I always tell you.
Laura: Do you remember that episode where I was telling you to eat a f****** yes, that is why I don't want.
Ron: To be to be honest, it's the specificity of the biscuit that I think caused the animosity around that as discourse.
Ron: Because, Laura, I don't want a f****** biscuit.
Ron: But what I do need to do is I need to hydrate, I need to sleep well, I need to look after myself, I need to go to the gym and I need to eat.
Ron: Because self care starts with the basics.
Laura: Yes.
Laura: Well, you're coming to see me this week, so I'll look after you for a week.
Laura: We will do cook along with Ron.
Ron: Because, Laura, you've gone from being kind of a hobo that lives in a house to kind of a more organised sort of person that has not only self care, but group care recently, right?
Laura: What do you mean?
Laura: A hobo that lives in a house?
Laura: What do you mean?
Ron: I think that's a fair description of how you and Tom used to live.
Laura: We were just cool cats.
Laura: Independent, free thinking hippies, that's what we.
Ron: I don't mean hobo as in a derogative term for a homeless person, I mean hobo in terms of kind of the cool American drifter sense.
Laura: Oh, yeah, I agree.
Laura: I was.
Laura: But, yes, life has changed.
Laura: So listen up, labyrinth.
Laura: I have a small announcement that I'm not ready to talk about on social media.
Laura: So if I could ask that, I'm going to tell you guys, and I really just want it to be with the listenership for now.
Laura: So if you wouldn't mind not tweeting me or publicly messaging me about it, I would really appreciate it.
Laura: Because I'm just not ready to talk about it on social media.
Ron: Shut up.
Laura: But it's getting harder and harder, not to mention on the podcast, and I love you guys quite a lot.
Laura: So I thought this can be my start of speaking about it.
Laura: There is now a child of the podcast, I Am a Mother, which is very exciting.
Laura: It's kind of new.
Laura: She arrived this year.
Laura: And it's really funny actually listening back to this episode because I really remember doing the Eggathon sitting next to the high chair we had just bought for our child and there I was cramming eggs into my mouth, thinking, how can I be both of these people at once?
Laura: So I wanted you guys to know and now we can talk about it freely on the podcast without trying to edit out any and all mentions.
Laura: But if you would be so kind as to just not let me have to deal with it on Twitter and stuff publicly, I would be very grateful.
Ron: Here's what you can do, listeners, because we love the community that we've built around this podcast.
Ron: Every single person that has ever interacted with this podcast, there's been a lighthouse of joy spinning around, slowly beaming out positive vibes to the world.
Ron: And we want to talk to you about this.
Ron: If you would like to talk to us about this, how about joining a special club called Patreon where your comments can be reacted to, listened to, read.
Laura: By us and other that's a really good point.
Laura: That's a good idea, Ron.
Laura: We can chat about it on the Patreon.
Ron: So we want to talk to you about it and that would be the best place to do it.
Ron: We don't have a discord, we don't have a reddit or anything like that, where it's a little bit more private.
Ron: That is our private space.
Ron: That is the fabrat lounge.
Ron: That's where we can discuss these kind of things.
Laura: Yeah.
Ron: Sorry to monetize your child instantly.
Laura: That's fine.
Laura: I'm not earning any other money at the moment, so there's got to be some way.
Ron: She's quite a money sink, I imagine.
Laura: I think they all are.
Laura: It's not like ours is particularly grabby for stuff.
Ron: No, but you, I imagine, want to please her quite a lot.
Laura: I do.
Laura: Are we saying I had an amazing no, I'm not no, I'm not going to be saying her name publicly.
Ron: Then we're going to call her Bill.
Laura: Child of the podcast.
Ron: Child of the podcast potty.
Laura: Yes.
Laura: Ratty.
Laura: Tiny rat.
Laura: What's a baby rat called?
Ron: A rattling.
Laura: A rattling we can't call a rattling.
Laura: I had a really nice moment where I was listening to because I was listening to the episode back before we do this bit.
Laura: And there was a bit where I was often one singing, obviously, and she started dancing to it and I was like, yeah baby, she loves mommy's interludes.
Laura: So it was pretty cool.
Laura: But yeah, uncle ron now exists.
Laura: Well, you were already an uncle.
Ron: I've been an uncle for many years, but first nieceling, and very keen for that because boys are gross.
Laura: Yeah.
Laura: So that's our sort of big announcement, really, and I'm really happy to share it with you guys.
Ron: Your big announcement.
Ron: I'm not going to take any spotlight on this.
Laura: No, Ron wasn't really involved.
Laura: No.
Ron: I don't know.
Laura: I provided massive emotional support.
Ron: I've not been a rock, but I've been a present pebble.
Laura: Yeah, I've got no complaints on your behaviour, Ron.
Laura: I've got loads of shortcomings of my own.
Laura: Turns out being a mum is f****** difficult.
Laura: If you think I'm bad at science, you should see me trying to be patient for 12 hours a day.
Laura: It's arguably harder.
Ron: If it's any consolation, and I've not said this to you before in person, nor via message, when things have been tense.
Ron: You're a wonderful sister, so I'm sure you're going to be a wonderful mother.
Laura: I'm really glad we haven't got the video on, because there's no way we could have got through that really beautiful moment if we were looking each other in the eye.
Laura: Thank you.
Ron: I'd have probably called you maybe a childful hag or something like that.
Laura: Yeah.
Laura: All right, well, enjoy the episode, fab and lab rats.
Laura: You're the bestest to people in the world.
Laura: And, hey, if you've been pondering whether or not to jump in on the patreon, let me tell you, now's the time to do it, because my earnings have dropped to zero and this podcast is all I have left.
Laura: So, hey, join up.
Laura: Let's monetize the child.
Ron: Monetize the child.
Laura: Enjoy it's unreal.
Laura: Okay, Ron, now, listen, listen, we're still very much in a post Eggathon world in real time here, so just look, I'll edit out as many burps as possible, but be aware, they are many more vomit.
Laura: That vomit didn't make it into the quiz.
Laura: I'd stopped recording.
Laura: Now you've just doxed me.
Laura: Yeah.
Laura: I was laughing so hard at you sneezing and the eggs in the twelve mixed up and I threw up in my cup.
Laura: Not my finest hour.
Ron: Quite bleak.
Laura: But look, here we are.
Laura: Oh, God.
Laura: They're still coming.
Laura: Still the egg gas moves.
Laura: How are you, Ron?
Ron: Egg?
Laura: Funny, funny.
Laura: We're back to biology today, though, aren't we?
Ron: Yeah, here we are.
Laura: One of my most said phrases.
Ron: That back to biology.
Laura: Fingers crossed this will be our first video episode.
Ron: OOH.
Laura: All right, wallace.
Ron: Yeah, it will be.
Ron: I don't like that in post egg sheen, but here we are.
Laura: Well, the X was all your idea, though.
Laura: Like, I don't want to get too tim and Tom the slap, but, like, at some point we will put eggs to bed and never reference them again.
Laura: But you created this egg monster.
Laura: Nobody asked for this egg situation.
Ron: The content was good, though, was it?
Laura: Good enough?
Ron: Maybe not for you to throw up in a cup.
Ron: But it wasn't throw up in a cup.
Ron: Good.
Laura: What's funniest about it, though, is that the funniest egg content is now not in the Eggathon.
Laura: After the Eggathon.
Ron: That's just a good advert for the Eggathon.
Laura: I love the layers.
Laura: I love it.
Ron: Right, we got a lesson to do here.
Laura: Seem dead.
Laura: Ron.
Ron: Egg.
Laura: He's egg dead.
Ron: Can you remember what we were doing last time?
Laura: The Human Defence System.
Ron: Yes.
Ron: You read that very quickly.
Ron: Well done.
Ron: Not the usual.
Ron: Oh, consult my book.
Ron: Russell, russell.
Ron: Russell.
Ron: Yes.
Ron: We were doing the Human Defence System and vaccination.
Ron: We were talking about colorblind teletubbies.
Laura: Yes.
Laura: No, that was a few episodes ago, the teletubbies.
Ron: Was it?
Laura: Yeah, last time was oh, no, it was that one.
Ron: Yeah, it's probably both ron.
Ron: It's probably both, though, isn't it?
Ron: Because the last biology episode was a few episodes ago.
Laura: Do you know how I know that is?
Laura: Because I've drawn the teletubbies in the book.
Ron: Yeah.
Ron: Oh, God.
Ron: I'm getting flashbacks to the teletubby babies now.
Ron: What have you seen?
Laura: Well, you're just coming through a bit quieter than me and I wanted to turn me down a bit.
Ron: That's nice.
Laura: Something wobbling where you are.
Laura: How sturdy is whatever mic setup you've made today?
Ron: It's fine.
Ron: I'm playing with stuff nearby.
Laura: Could you stop?
Laura: Could you stop?
Ron: Yeah.
Ron: So, today we're going to be doing antibiotics and painkillers.
Laura: OOH.
Laura: Take the painkiller cycle on my bicycle leave all this misery behind.
Ron: You'Ve got a song for a lot of words?
Laura: Yeah.
Laura: My brain makes connections real fast.
Ron: What if I said tube tubular?
Laura: That's what I do.
Ron: That's not us.
Laura: Or then I'd quickly go, I don't know how it goes, but they're like that one.
Ron: I don't know what else.
Laura: Tubular Bells.
Ron: Not like Tubular Bells was part of the soundtrack of the Exorcist.
Laura: How would you sing?
Laura: Tubi the bells.
Ron: I can't remember how to be the.
Laura: Bells goes ding, ding, ding, ding, ding, ding, ding, ding, ding, ding, ding.
Laura: Get the ghost out.
Laura: Ding, ding.
Laura: Oh, she's spewing egg everywhere.
Ron: Puzz eggs.
Laura: The eggs.
Laura: She's having an existential crisis.
Ron: What's quite nice is that in post tricko life, something has eclipsed that.
Ron: There's eggs.
Laura: Yeah, it's eggs, man.
Ron: It's eggs.
Ron: Eggs are just funny, though.
Ron: In the Always Sunny podcast, they talk about why they always reference eggs and stuff and they're just like eggs.
Ron: They basically just say there are some things that are just inherently funny and eggs are one of them.
Laura: I'm worried that your thing isn't picking you up through your microphone.
Laura: Can you cheque that you're coming in through your microphone?
Laura: Can't hear you at all now.
Ron: Oh, I muted myself, but I am.
Laura: That's better.
Ron: It was the same.
Laura: Okay, then you need to be closer because you're barely even making the green thing flick sometimes.
Ron: Oh, okay.
Ron: Is that better?
Laura: Yeah.
Ron: Okay, I can do that.
Ron: So, antibiotics, laura, what do you know about them?
Ron: What have you been lied to about them in the past.
Laura: Didn't we talk about them last time?
Laura: They like, get in and they do a course of action on you, but they have to completely kill the bacteria that they're fighting, otherwise that bacteria learns how to defeat them in the future.
Ron: I think we've talked about it, but I don't think we really have.
Ron: We done did we do antibiotics last time?
Laura: Yeah, I thought we did.
Ron: Well, we're going to do it again.
Laura: How come?
Laura: What did we miss?
Ron: I don't remember doing it.
Laura: Let me consult the book.
Laura: We did phage, go, Titosis antibody production, bacteria having little markers on them.
Laura: Yeah, actually, didn't we do antibiotics post tricho?
Ron: No, we did antibiotics as part of the tricho, but famously, that was bollocks.
Laura: After the tricho, we did prokaryotes, cockeye, baccalae bacteria, salmonella.
Ron: Yeah, but we didn't do antibiotics, did we?
Laura: I don't know.
Ron: None of the things that you've just listed were antibiotics.
Laura: Oh, my God.
Laura: Then, well, you do some f****** research for once.
Ron: I have.
Ron: I do all of the content prep.
Laura: And yet here you are saying, have we already done this?
Ron: Well, no, because I was like, let's do this, and then you were like, We've already done it.
Laura: Those are my lunches.
Ron: Bring back.
Ron: That classic.
Laura: Come on then, we know.
Ron: So what do antibiotics do?
Laura: Kill off diseases.
Ron: Which diseases?
Laura: Infections.
Ron: Which infections?
Laura: Baddie ones.
Ron: Do you take antibiotics if you've got a cold?
Laura: No.
Ron: What type of thing is a cold?
Laura: A virus.
Ron: Okay, so we can exclude viruses, can't we?
Laura: Yes, we can.
Laura: Get out.
Ron: Do you take antibiotics if you have athletes foot or athletes v*****?
Laura: No, not for fungal infections.
Ron: Not for fungal infections.
Ron: So do you take antibiotics for malaria?
Laura: Maybe?
Laura: I've never had it.
Ron: If you did, do you think malaria would be the sizable problem that it is?
Laura: No.
Ron: So we can rule out protists then, probably as well, can't we?
Laura: Yeah.
Ron: So when, Laura, do you take antibiotics for other diseases?
Ron: Which one?
Laura: Well, I don't know, Ron.
Laura: If I knew, I'd have said it earlier.
Ron: Well, we've just ruled most of them out, haven't we?
Laura: So what's the last one, then?
Laura: Say that one and then say, Would you take antibiotics for those?
Laura: And I'll say yes.
Ron: Just no.
Ron: What's the one that's left?
Laura: Eukaryotes.
Ron: Is that a type of disease?
Laura: I don't know.
Laura: Oh, my throat is kind of gummy.
Ron: It's because it's full of egg, chocolate and vomit.
Laura: I think in hindsight the chocolate was bad.
Ron: Yeah, I ate chocolate right after it.
Ron: I ate chocolate curing.
Ron: It's a big chocolatey egg puree in me right now.
Laura: Airborne viruses, is that a type of.
Ron: Thing or is that a description?
Ron: What's the other one?
Laura: I don't know, Ron.
Laura: Look back.
Ron: That just means something that infects things.
Laura: Work done.
Ron: He's got a bad brain.
Laura: What have I got?
Laura: Down.
Laura: Fungals.
Ron: We ruled them out, didn't we?
Laura: Yeah.
Laura: Bacterial infection?
Ron: Yes.
Ron: Okay, so when do you take antibiotics, Laura?
Laura: After they've been prescribed by a doctor?
Ron: Yes.
Ron: To treat what?
Laura: Bacterial infections.
Ron: Very well done.
Ron: Clap.
Laura: Right.
Ron: Okay.
Ron: Good job, Laura.
Ron: Well done.
Ron: We got there.
Ron: So we'll talk a bit more about how do we'll talk a bit more about antibiotics?
Ron: Antibiotics are essentially chemicals that just fight bacteria.
Ron: Kill them.
Ron: They don't, obviously kill human cells.
Ron: It's not kind of like a radiotherapy or chemotherapy situation.
Ron: It's not making us sick, is it?
Ron: Is it?
Laura: No.
Ron: So how do you think unless you.
Laura: Drink alcohol with antibiotics yeah.
Ron: How do you think antibiotics kill bacterial cells but not human cells?
Laura: Get the markers on them.
Ron: No, there are some things that people are developing that's a bit like that, but that's quite an advanced thing because to create a marker for a specific bacteria is quite crazy.
Ron: It'd be quite hard.
Laura: So do they is it something to do with the size of the cells?
Ron: No, but you're on the right track.
Laura: Little I can make my lips.
Ron: You've got a bad brain.
Laura: I don't know, Ron.
Laura: I can't imagine.
Ron: Can't imagine what?
Laura: How they're doing it.
Ron: Well, are bacteria and human cells the same?
Laura: No.
Ron: We've been recording this podcast for over a year now yeah.
Ron: And just really nothing's gone in.
Ron: Honestly, it's kind of impressive, the lack of retention.
Ron: I think you'd make a wonderful spy because I think we could tell you all the secrets of the universe.
Ron: It slide off you like s*** off a duck's back.
Laura: Yeah.
Laura: It doesn't stay in at all.
Laura: And I'm not putting it on.
Ron: No, I know.
Ron: Because you're so proud when you do remember something and you crave that attention that you never get.
Laura: I don't ever get it.
Ron: Do I know you never deserve it.
Laura: I do deserve it, because I'm nice.
Laura: If we did a podcast where the whole point was to be really nice all episode yeah.
Ron: But then I would get Lexx.
Ron: Nice.
Laura: Lexx be nice to each other.
Laura: Just a podcast about nice things.
Ron: There's a new Patreon episode we can do.
Laura: I found a page about cells, but I didn't think that all human cells were the same.
Laura: I didn't know that we all our cells were the same type of cell.
Laura: I thought they varied.
Ron: They do vary a bit.
Ron: But they're all human cells.
Laura: They're all prokaryotes.
Ron: Are they?
Laura: Yes.
Laura: No, they're all eukaryotes.
Ron: They're all eukaryotes.
Ron: Other things that are eukaryotes include plant cells, but plant cells are different to human cells.
Laura: They have a cell wall.
Ron: Exactly.
Ron: Yeah.
Ron: There's fundamental differences like that.
Ron: So are bacterial cells and human cells the same?
Laura: No.
Laura: I reckon bacteria are probably pokarots.
Ron: Pokaryotes.
Laura: Yeah.
Laura: Prokaryotes.
Ron: Is that going back to the Telly.
Laura: Tubby PO carry oats.
Laura: Oh, the tubbies are having tubby porridge.
Laura: Tub.
Laura: Tub.
Laura: Tub.
Laura: Hey, wouldn't I be a cool teletubby now with my painting above my head like a fire cracker?
Laura: Telly tubby.
Ron: Tinky Winky's playing with his ball gypsy's playing with his hat.
Ron: Laura's stuck under the tubby toast machine again.
Laura: Oh, yeah, because prokariats are like the small ones, aren't they?
Laura: They are proletariat and the eukaryots are the eukaryote.
Laura: I'm the bourgeoisie.
Ron: So we've identified now, very astutely between the two of us, that can you.
Laura: Talk in a nicer way that doesn't make me feel like a tiny worm, please?
Ron: I think we're having a nice episode here.
Ron: There's a cool cloud over there that looks like the Sorting hat or maybe a spaceship.
Laura: Pick up my phone in a minute if you don't start.
Ron: As a team, we've worked out that bacteria and human cells are not the same.
Ron: So how do you think that antibiotics you've already picked up your first.
Ron: How do you think antibiotics might target bacterial cells but not human cells?
Laura: They only hit up prokaryotes.
Ron: Yes.
Ron: And how?
Laura: And how?
Laura: They only attack prokarotes.
Laura: And how?
Laura: Think about it this.
Ron: If I was to make a weapon that only killed elephants and didn't kill dogs, how could I do that?
Laura: Wouldn't it be the other way around?
Laura: Aren't the prokaryotes smaller than these?
Ron: Don't think no, I'm just asking you the question.
Ron: If I wanted to create a weapon that only killed elephants and didn't kill dogs, how could I do that?
Laura: Put it up high.
Laura: Higher than a dog is razor wire.
Laura: Razor wire tied between two trees just at, like, elephant trunk height.
Ron: Yeah.
Ron: What about other things?
Ron: How else could I make an elephant specific weapon that would leave a dog unscathed?
Ron: Because again, you've identified size difference.
Laura: Yeah.
Laura: Colour difference.
Laura: Have a grey no, that doesn't count.
Laura: Grey weapon.
Ron: But you do get some grey dogs, don't you?
Laura: Lord.
Laura: And also the knife.
Laura: It doesn't matter what colour it is, it'll cover anything.
Laura: I think you'd have a grey knife.
Laura: Have something that can't go through hair.
Ron: That could work.
Ron: Yeah.
Ron: Or maybe all right, what about this?
Ron: What if I had a robot that tied trunks into knots?
Ron: That would kill an elephant.
Ron: Eventually.
Laura: It would kill an elephant.
Ron: Yeah.
Ron: But they wouldn't be able to use their trunk.
Ron: They'd starve to death horribly.
Ron: That would kill an elephant.
Laura: Elephants would come along and feed them.
Laura: They work as team.
Ron: It's one elephant and one dog alone in an arena.
Laura: The dog would help the elephant, I think.
Ron: No, it wouldn't.
Ron: They had mortal enemies.
Laura: Oh, no.
Laura: Why?
Ron: The elephant stamped on the rest of the dog's family.
Laura: Oh, no.
Laura: Then get the dog to tie the trunk in a knot.
Ron: No, but the point is, after you've gotten over your egg vapours the point is, if I had a machine that just tied trunks in knots, that's going to affect elephants, but not dogs.
Laura: What if it got confused and tied a dog's tail in a knot?
Ron: Shut up.
Ron: It only ties trunks.
Laura: It might just think it's a turned round elephant.
Ron: It doesn't.
Ron: It's the perfect trunk dying machine.
Ron: You're derailing my point.
Laura: That's my job.
Ron: So I've got something that affects trunks.
Ron: Or maybe it goes for the ears.
Ron: Big ears.
Laura: Some dogs have big ears.
Ron: Pardon?
Laura: Some dogs have big ears.
Ron: Not as big as an elephant ears.
Laura: No wonder.
Laura: What dog has the biggest ears?
Laura: What dog has the biggest ears?
Laura: Bloodhounds.
Ron: WhatsApp?
Ron: To me, a shopping list.
Ron: Quite rude, actually.
Laura: Bloodhounds.
Ron: Ron okay, so you see what I'm saying?
Laura: You can not at all.
Laura: I'm really lost.
Laura: What are we talking about?
Ron: So if you wanted to make something that would only affect one thing, you could potentially design it to go after things that only one of them had.
Laura: Can only get better.
Laura: Yes.
Laura: Okay, so let me have a look and see what prokaryotes have that eukaryotes don't have.
Ron: Yes.
Ron: Well, not necessarily all eukaryotes, because we're talking about humans, aren't we?
Ron: Aren't we?
Ron: Well, animals.
Ron: Because you don't give antibiotics to carrots, do you?
Ron: Do not, no.
Laura: Kit in.
Ron: What's?
Ron: That what's made of kitin?
Laura: Well, I've just written the sentence.
Laura: Kitin is what to the cell wall and then it stops.
Ron: Chitin is what to the cell wall.
Laura: Just chitin is what to the cell wall.
Laura: Okay.
Ron: Why have you written that?
Laura: I don't know.
Ron: That's not a good sentence, but yes, a cell wall is the answer.
Laura: Cell wall?
Ron: Yeah.
Laura: So antibiotics go after cell walls?
Ron: Well, they could, and a lot of them do.
Laura: Okay.
Laura: Antibiotics often attack cell walls with trumpets and the walls came crumbling down.
Ron: But that's not necessarily but you see what I mean?
Ron: That antibiotics go after the things that bacteria have that animal cells don't.
Laura: Got you.
Ron: Okay, can you just sort of maybe summarise the last 25 minutes of chat?
Ron: We'll just do a quick double cheque that you get it and then we can move on.
Laura: Hang on, I'm still writing.
Laura: If I sing now, I don't have to find a sound effect.
Laura: Okay.
Laura: Antibiotics are for fighting bacterial infection.
Laura: They only target bacteria which are prokaryotes, and they do that by targeting them and not the other ones.
Ron: How.
Laura: F****** by going after them.
Ron: How?
Ron: If they just went in and f***** up DNA, would that just kill the bacteria?
Ron: No, because human cells have DNA as well, don't they?
Laura: Yeah, that's what I mean.
Laura: They only go after the bits that are them.
Ron: But that's not what you.
Laura: Know what I mean?
Laura: They go for the bits that aren't a person in the person cells, such as cell wall.
Ron: Yeah.
Ron: Great.
Ron: Well done.
Laura: Thank you.
Ron: Can you name any antibiotics?
Ron: Lauren.
Laura: No.
Ron: You can't name one.
Ron: Antibiotic.
Laura: Penicillin.
Ron: Yes, very famous thing.
Ron: Do you know who discovered penicillin and how it was done?
Laura: Was it oh, they were talking about this.
Laura: The lab rats were talking about this on Twitter.
Laura: Jenna.
Laura: Edward jenner.
Ron: No, the lab rats weren't talking about this.
Ron: They were talking about vaccines.
Laura: Louis Pasteur.
Ron: No, he did pasteurisation.
Ron: That happens quite a lot.
Laura: Penicillin was Mary Curie.
Ron: Well, no, because she did radiation, didn't she?
Ron: Died of it.
Laura: She might have done another thing.
Ron: One trick pony.
Laura: No.
Ron: She got two awards for the same thing, probably.
Laura: Brilliant.
Laura: Well done.
Laura: Her.
Laura: Submitted it twice.
Laura: Penicillin, you could say.
Ron: No.
Laura: John Smith.
Ron: No.
Laura: Greg Rosetski.
Ron: No.
Ron: The first name is a name we almost share.
Ron: The second name is the name of the family that Megan was friends with around the corner in Norton.
Ron: Fitz Warren.
Laura: ALexxander Fleming.
Ron: Yes.
Ron: Well done.
Ron: And do you know how it happened, how the story goes?
Laura: Oh, he left, like, a sandwich on the windowsill and it went bloomy and they ate it and it killed him.
Laura: It cured his stuff grew mould accidentally, didn't he?
Laura: And got it off mould.
Ron: Yes.
Ron: He didn't eat a rotten sandwich and he himself.
Laura: But kind of essentially, if you miss a few steps, that's what happened.
Ron: If you miss out the sandwich and the eating.
Laura: It was mould, though, isn't it?
Laura: I've always pictured it on a sandwich.
Ron: No, it wasn't on a sandwich, though.
Laura: What was it on?
Ron: Basically, yeah, it was a petri dish.
Ron: He didn't clean up after himself after doing an experiment.
Ron: Comes back to the lab after some time and notices that his petri dishes have gone mouldy.
Ron: But he looks at it and there's mould there and around certain colonies of mould, there's like a blank space before your name.
Ron: Other colonies.
Ron: So he deduces that the mould that had the blank space around it was producing something that was killing the bacteria.
Laura: Yeah.
Laura: And then he ate a sandwich.
Ron: He might have eaten sandwiches.
Ron: Maybe.
Laura: Sandwich has been invented, then.
Laura: That was the Earl of Sandwich, wasn't it?
Laura: Sandwich apocryphally.
Laura: He wanted something he could eat whilst at the gaming table that wouldn't disrupt his playtime.
Ron: Yes.
Ron: Don't sell lies to try and make yourself seem smart.
Ron: Yes.
Ron: Sandwiches were about 150 years old at.
Laura: This point, but then they were f****** mouldy.
Laura: They've definitely got a yellow sticker on them.
Ron: But ALexxander Fleming only grew more powerful the more he ate.
Ron: It felt like your attention drifted towards the end of that.
Laura: Ron, what if someone handed you an egg sandwich right now and said, do you have 10,000 pounds if you eat this, would you eat it?
Laura: It's just slices of dry boiled egg.
Ron: On white bread, no mayo.
Laura: I boiled the eggs.
Ron: No mayo.
Laura: No.
Ron: For ten grand?
Ron: Yeah.
Laura: All right.
Ron: Would you?
Laura: Yeah.
Laura: I'd do anything for ten grand.
Laura: I just ate four eggs for about six pounds for nothing for 6 hours.
Laura: We were getting anyway.
Ron: God, life's relentless.
Laura: Hey.
Laura: We're having a good time.
Ron: Yep.
Ron: Throwing eggs up in cups.
Ron: Antibiotics such as penicillin are medicines that help to cure bacterial disease by killing infective bacteria inside the body.
Ron: It is important that specific bacteria, like.
Laura: The facts, are always in these little bits, these rambles that you go on after we've done a bit.
Laura: And that's where I fall down with this podcast is you do a bit like this and I go, oh, it's a rhombit now.
Laura: But this is where the information is, isn't it?
Ron: Well, yeah.
Ron: This is when I'm reading from the syllabus.
Ron: Yeah.
Laura: I think that's a mistake I've been making.
Ron: You're doing yourself a disservice to say that you're falling down during those.
Ron: You were never up.
Laura: I've got loads of it right so far.
Ron: Have you?
Laura: And when I was only halfway up, I was neither up nor down.
Ron: You said that to kill an elephant, we need to stab it with a grey knife.
Laura: I didn't, actually.
Laura: I said no and then just explained the thought I had had and how I knew it was already wrong.
Laura: I did say it was wrong before it happened, actually.
Ron: Ron yeah.
Ron: Funny.
Ron: Why do you think it's important that specific bacteria are treated with specific antibiotics?
Ron: Maybe.
Ron: You don't think that's important?
Laura: I never really have to take antibiotics.
Laura: Mackie had antibiotics recently.
Laura: Are they quite specialised?
Ron: Yes.
Laura: So maybe some antibiotics are better at, like, a cell wall.
Laura: Some of them are better at other things that bacteria have that human cells don't have.
Laura: So they just sort of do it like that.
Laura: Right tool for the right job, basically, yeah.
Ron: So not all bacteria are the same.
Ron: They have different characteristics and sometimes just stuff like the cell wall, the makeup of the cell wall will be slightly different.
Laura: So one bacteria might come in a strong contouring.
Laura: You might just gone for a cut crease.
Ron: Some bacteria have membranes outside the cell wall, so if you've got an antibiotic that goes straight for the cell wall, if they've got a membrane outside it, they can't get there, can they?
Laura: No.
Ron: Do you think antibiotics have greatly reduced or greatly increased deaths from bacterial diseases?
Laura: Massively reduced, yeah.
Ron: Says that here the use of antibiotics has greatly reduced if you just egg vape it again.
Ron: Yeah.
Ron: However, what's the downside to antibiotics?
Laura: Laura I think they get used up, get antibiotic resistance to them in the colonies of bacterias.
Ron: Yeah.
Ron: And do you remember how that worked?
Ron: We have talked about that before.
Laura: You don't finish the course and then the bacteria learns what to do to defeat that antibiotic.
Ron: Well, the bacteria doesn't necessarily learn because it evolves.
Ron: Yeah.
Ron: It's a selective pressure.
Ron: I think we had this conversation before.
Laura: Antibiotic pressure.
Laura: Pushing down on you.
Ron: Pushing down on you.
Laura: Selective pressure.
Ron: You're a lot more on when we're recording the video.
Laura: I'm like a budgie.
Laura: Also, I've eaten four eggs in a twelve.
Laura: I'm an absolute picnic right now.
Ron: What was I saying?
Ron: Yes, it's a selective pressure.
Ron: Do you remember our flying reindeer?
Laura: Yes.
Ron: Think of antibiotics as a rat carpet that the bacteria needs to escape from.
Ron: But instead of flying the evolutionary way out, you've gone cross eyed and very blank.
Ron: Are you looking at something or has this confused you?
Laura: I'm looking at you.
Laura: I'm thinking about.
Laura: The rat carpet again.
Ron: Yeah.
Ron: So rather than flying away from a.
Laura: Rat carpet, the bacteria illustrated by Raymond Briggs in my head, the island that we made.
Ron: Yeah.
Ron: Instead of doing that, it will involve resistance to an antibiotic.
Ron: So maybe it changes the makeup of the cell wall so that the molecular structure fits in the active site of the enzyme of the antibiotic.
Ron: Worse.
Laura: Yeah.
Laura: Pepper.
Laura: She's got no lips.
Ron: Laura?
Laura: Yes.
Ron: Can antibiotics can antibiotics kill viral pathogens?
Laura: No.
Ron: Yes.
Ron: Good.
Ron: Are painkillers antibiotics?
Ron: No, they're not.
Ron: Painkillers and other medicines are used to treat the symptoms of disease, but do not kill pathogens.
Ron: Okay.
Laura: Yeah.
Ron: It is difficult to develop drugs that kill viruses without also damaging the body's tissues.
Ron: Do you know why that is?
Laura: I guess just because some cells are probably going to have some of the features that you've trained the antibiotics to kill, so there's going to get some friendly fire caught in the crosshairs.
Ron: But we're talking about viruses in that sentence, aren't we?
Laura: Say the question again, then.
Ron: It is difficult to develop drugs that kill viruses without also damaging the body's tissues.
Laura: Is it because viruses are eukaryotes?
Ron: Are they eukaryotes?
Laura: I don't know.
Laura: I don't really know what they are.
Laura: No.
Laura: Wait.
Laura: Does a virus get in your own cells?
Ron: How does a virus reproduce?
Laura: Gets in your own cells and uses your ATP.
Laura: So you kind of have to hurt you a bit to scoop them out because they're hiding.
Ron: Exactly.
Ron: Yeah.
Ron: So they don't have the machinery that they need to reproduce themselves.
Ron: So they invade ourselves and do it in there.
Laura: Yeah.
Ron: Okay.
Laura: Poor things.
Ron: And that's antibiotics and painkillers.
Laura: Wonderful.
Ron: Yeah.
Ron: Should we go on to the next bit or do you want to stop?
Laura: We'll do the next bit.
Laura: I'm having a lovely time.
Ron: All right.
Ron: Discovery and development of drugs.
Ron: Laura, what's your favourite drug?
Laura: Oxytocin.
Ron: Nice.
Laura: Followed closely by searcherlene.
Laura: This podcast is sponsored by delicious.
Ron: Delicious search.
Ron: Lean.
Ron: Um, students should be I haven't prepared this bit, so it's going to be a bit ramshackle.
Ron: Students should be able to describe the process of discovery and development of potential new medicines, including preclinical and clinical testing.
Laura: I can't do that.
Ron: Okay.
Ron: Traditionally, drugs were extracted from plants and microorganisms.
Laura: Can you you know when you said to me, did I want to carry on, I think maybe what you should have said is we shouldn't carry on.
Ron: Why?
Laura: Because you just yawned whilst just reading out a bit that you hadn't already read, so you didn't know what was happening and now you're just looking a bit glazed and just kind of we're suddenly into end of term final period lesson.
Ron: Maybe I'm tired.
Laura: Yeah.
Ron: Traditionally, drugs were extracted from plants and microorganisms.
Laura: Come back to your microphone so we can hear.
Ron: Traditionally, drugs were extracted from plants and microorganisms.
Ron: Laura, can you think of an example.
Laura: Of when aspirin comes from the bark of a willow tree?
Laura: Thank you.
Laura: Tim mentioned.
Ron: Very good, very effective and almost side effect free.
Ron: Can you think of another one?
Laura: Opium.
Ron: It's not really the type of drug that we're thinking of.
Laura: You didn't specify that.
Laura: So ding.
Ron: All right.
Ron: Ding.
Ron: And another one?
Laura: Ragwart.
Ron: What's that?
Laura: I don't know.
Ron: Let's put that in the no box, then.
Ron: Can you think of another one?
Ron: Dock leaves that's pseudoscience which Dr Mumbo Jumbo of the playground.
Ron: No.
Ron: Can you think of another one?
Laura: Chamomile.
Ron: That's t.
Ron: Can you think of another one?
Ron: Potentially one that we've been talking about?
Laura: Penicillin.
Ron: Yeah, there we go.
Ron: So you actually named two on the list that I've got in front of me.
Ron: There the painkiller aspirin, which originates from the bark of the willow tree.
Ron: And penicillin, which was discovered by ALexxander Graham.
Laura: Fleming bell.
Laura: ALexxander Fleming.
Ron: Jesus.
Ron: From the penicillium.
Ron: Mould.
Ron: The other one is do you know what we got from Fox?
Ron: Gloves.
Ron: You can say no.
Laura: Night Shade.
Ron: No.
Ron: The heart drug.
Ron: Digitalis.
Ron: James Bond fans will know that this is what James Bond is poisoned with in Casino Royale when he has to make himself throw up and then run out to his car.
Ron: And then Eva Green comes out and then she shocks him and then she's like, we're going to a hospital.
Ron: And then he's like, no, I'm going to go finish playing cards.
Ron: Did you watch that YouTube clip I sent you the other day, Laura?
Laura: No.
Ron: Why not?
Laura: I thought it was just taffin.
Ron: Yeah.
Laura: I've seen it before.
Ron: I thought you'd think it was funny.
Ron: It's like an Adam and Joe thing.
Laura: Yeah, but have you not ever watched it before?
Ron: Yeah, but I just thought you'd at least be, like just ignored it.
Laura: Yeah, you need ignoring sometimes.
Laura: No.
Laura: Yeah.
Laura: I don't often watch videos people send me, but sometimes I just reply and say, Ha.
Ron: Yeah, that's what everyone does.
Laura: I don't really like watching other people's videos.
Ron: Just watch your own.
Laura: I just watch just my Roast Battle and stuff.
Ron: Most new drugs are synthesised, synthesised by chemists in the pharmaceutical industry.
Ron: However, the starting point may still be a chemical extracted from a plant.
Laura: So it's very 80s vibe, lots of synths.
Laura: It's a musical joke.
Ron: New medical drugs.
Ron: Laura, do you think they just start selling them without checking if they work?
Ron: Or do you think that they're tested and trialled before being used to cheque, that they are safe and effective?
Laura: Well, Ron, I think it's a bit of a blurry area.
Laura: I think they are tested.
Laura: I don't necessarily think they come out the other side of that safe.
Laura: I think that the system is very open to exploitation.
Ron: Why?
Laura: Because I read a really good book all about the family that invented OxyContin and all about the under the table deals and stuff that go on in terms of what has to be put on the packaging and how they get them to market.
Laura: It's the book that the programme Dope Sick is based on about the Chancellor family and the OxyContin opioids crisis in the US.
Ron: Interesting.
Laura: Really good book.
Laura: One of those nonfiction books that reads like you read it like fiction.
Laura: It's great.
Ron: Yeah, there's lots of stuff.
Ron: There's lots of interesting points about stuff like this, especially going back a bit.
Ron: A lot of medicines would be only tested on white people or white men and stuff like this, and then completely just ineffective or in some cases, completely dangerous for other groups of people and stuff.
Laura: Yeah, that sounds about right.
Laura: Tom and I were talking today, we went and did a food shop and I was saying how, like, being a woman, and for me, being a small woman means I'm very small compared to the average of stuff.
Laura: So, like those deep trolleys, I can't use them, I can't get stuff out the bottom of them once they're in.
Laura: And that's a real minor thing about how much the world is not really built for me.
Ron: Well, I was reading a really interesting book about that, invisible Women.
Laura: Oh, yeah?
Laura: Caroline Creardo Perez.
Ron: Yeah, I haven't finished it, but that was super interesting.
Ron: All of the stuff about the public transport in cities and women by far make the majority of journeys on public transport, and they usually are doing it around their sort of local area.
Ron: But all public transport in all major cities is designed in a radial way to just get from outside the city to in, because that sort of supports traditionally, like the man of the house going into the city to do his big important job, even though that is by far not the way that most public transports used.
Ron: And yeah, redesigning public transport to actually just let people get around their local area would help the majority of people a lot.
Laura: But then we're giving into this 15 minutes city idea on and then we're just slaves.
Laura: That is a joke, by the way, everybody.
Laura: I do not think that they are a conspiracy.
Ron: With a lot of this stuff, you can at least pull the thread and work out where it's come from and you can see why they feel like they're being attacked or something because they've been told X or they've been told Y.
Ron: The 15 minutes city thing has completely escaped me.
Ron: I don't understand at all why you'd object to having things close to you.
Laura: I think it's the fear that we will then be penned into these 15 minutes areas that like the idea is that the government don't want you to leave your 15 minutes area.
Laura: Not, oh, we've made it convenient if you can't, but you go wherever you like.
Laura: That's great for capitalism.
Laura: No, I think their fear is that that will be it, then they'll be sort of kept in.
Ron: But that is so catastrophically dense.
Ron: How could you ever believe that was going to happen?
Laura: I guess you're just very distrusting by that point.
Laura: And so sort of everything looks suspicious, bizarre.
Ron: Let's blow through this.
Laura: That's the spirit, ron New drugs.
Ron: This is boring.
Ron: New drugs.
Laura: You can't say that the biology is boring because now we just got two more weeks of absolute shocking chemistry.
Ron: After this, we'll get into more interesting stuff, but like, oh yeah, we test it, we see if it's safe.
Ron: Yeah, of course you do.
Ron: New drugs are tested for toxicity, efficacy and dose.
Ron: Preclinical testing is done in a laboratory using cells, tissues and live animals.
Ron: Clinical trials use healthy volunteers and patients.
Ron: Very low doses of drugs are given at the beginning of a clinical trial.
Ron: If the drug is found to be safe, they can up the dose to find the optimum.
Ron: In double blind trials, some patients are given a placebo.
Ron: All right, that's drugs.
Ron: Next time we'll be on to bioenergetics.
Laura: That sounds fun.
Ron: I think you'll hate it a bit, but fun.
Ron: Fun.
Laura: Till my daddy took the Tbird away.
Laura: Okay.
Laura: Thanks, Ron.
Ron: Thanks, Laura.
Laura: See you for quizzing time.
Ron: Quiz up.
Laura: Okay, quiz recording.
Ron: Now, there's been a lot of talk recently, laura there always is, Ron, about Ron phoning in the quizzes and not putting any effort and just being bad at them.
Laura: Well, you do hate them and I.
Ron: Think a lot of the talk is coming from me.
Laura: You shouldn't chatting to yourself, Ron.
Ron: And the first thing I'm going to tell you is going to corroborate that somewhat, but the second part of this is going to uncorroborate, it's going to robot.
Ron: Okay, so I've completely forgotten what we've done over the past two biology lessons.
Laura: Yeah.
Laura: To be honest, peek behind the curtain, which you and the listeners love.
Laura: I forgot that we'd recorded this episode.
Ron: That was the big f****** chat of the week that we should have been chatting about is it was, do you want Lolly swish podcast with noise, jangles and edits?
Ron: What do you want?
Laura: No, you can't do this.
Laura: So you need to go back to episode 45 where Laura's mad at Ron for not making the notes properly.
Laura: That's what Ron's now talking about here in the quiz of episode 49.
Laura: Just I need you to know that f*** Ron.
Ron: And the question was, do you like a swish podcast with sound effects and everything, or do you want a more sort of Earthy granola kind of podcast that has sort of like a bit of a peek behind the curtain, sort of a slice of life kind of thing?
Ron: And you know what?
Ron: The people rallied together and said, f*** me, I want both.
Ron: Yeah.
Laura: That's great, Ron.
Laura: I just wish we'd discussed this four weeks ago when people were talking about it not just 45 minutes into this episode.
Ron: Eggathon soluble soul.
Ron: All of the current stuff that is happening in the zeitgeist of this podcast.
Laura: How people don't just download this and their phone just vomits it back out like, no.
Ron: It'S a web.
Laura: It is a web.
Laura: It's such a mess.
Ron: Anyway, so I've completely forgot we've covered over the last two episodes because I think even in the last episode, I think we ended up kind of backtracking and double covering something that we covered in the episode before.
Laura: Yeah, we kind of did antibiotics and antigens and stuff.
Ron: Yeah, but we'd kind of covered some of it before.
Ron: So what I've done is we're just going to do a semi sort of revisiony kind of quiz and we're going to cover it all again.
Ron: One off, and then we're onto a new topic next time.
Ron: Dunzies.
Laura: Okay, so in my defence, some of this that you're about to ask me was weeks ago.
Ron: Yeah, but it's been simmering in the brain.
Laura: Got you.
Ron: So, Laura, can you name three non specific defence systems that your body has against pathogens?
Laura: Can you define nonspecific?
Ron: Why don't you try and muscle it out and I'll guide you?
Laura: Nose.
Laura: Head.
Ron: Sorry, Celia, is this you muscling it out?
Ron: I thought you were going to muscle out.
Ron: What non specific muscle out mean?
Ron: Muscle it out.
Laura: What does that mean?
Ron: I don't know.
Ron: Just brain muscle fLexx.
Ron: That rock hard brain.
Laura: Do you mean like immune system?
Ron: I don't know.
Ron: Do I?
Laura: I don't f****** know.
Laura: What do you mean by nonspecific?
Ron: Well, what does non specific mean?
Laura: All right, skin, immune system and acids in your holes.
Ron: Final answers.
Ron: Yeah, two out of three.
Ron: And that ain't bad because the immune system, like, when you have, like, a white blood cell or something, it protect, will attack, like, specific pathogens and stuff, won't it?
Laura: I don't know.
Ron: Okay, that might like I said, I.
Laura: Don'T know what you mean by non specific.
Ron: Well, non specific is in.
Ron: Like, the acid in your stomach will kill anything that goes in it.
Ron: Your skin will keep out any pathogen.
Laura: Right, well, if you just told me that, like, non targeted because my immune system does just nonspecifically keep me well, you didn't say it was targeting specific pathogens.
Ron: You know, though, these podcasts like an hour long, and the first 45 minutes, me telling you these sort of things.
Laura: But not this week.
Laura: Another week you did this.
Ron: Maybe.
Ron: Name three ways that white blood cells protect your body.
Ron: Three ways that they deal with pathogens.
Laura: Oh, we got an Eggathon.
Laura: Patron.
Ron: Yes.
Ron: Leanne Langdon.
Ron: Come on down.
Laura: Are you happy now?
Laura: You're sad that we put the video out a couple of hours ago and no one had signed up yet?
Ron: I just couldn't believe anyone could resist.
Laura: Yeah, it's true.
Laura: I can't believe we haven't lost patrons.
Ron: We might have done.
Ron: I don't think we've got email alerts for that.
Laura: So many eggs.
Ron: What are you going to do for your bank holiday?
Ron: For the coronation?
Laura: I don't really care about bank holidays.
Laura: I work when I want to.
Laura: I'm not a slave to the meat grinder rat race.
Laura: That's it.
Ron: Muscle it out.
Laura: I was like, I'm not a rat on the tube.
Laura: That's not yeah, I'm not in the rat race.
Laura: Rat race, rat race, rat race.
Laura: I can't remember what was tricko and what was real.
Laura: Do they, like, gang up on pathogens?
Laura: Do lots of white blood cells just get round them and grump them?
Ron: You name your three and then I'll tell you which ones you got.
Laura: Right, name three.
Laura: What?
Ron: Three ways white blood cells protect your body from pathogens?
Laura: I think sometimes they swallow them in the vesicles, sometimes they barricade them in.
Ron: Ignore that.
Ron: I was laughing at something else that might be right.
Laura: Oh, hang on.
Laura: They've got teletubby heads on and they get a key that matches the bacteria's tattoos and then they cancel them out.
Ron: You need to do better.
Laura: Um oh, they've got a lymph node library.
Laura: Phageotitosis.
Laura: That's the.
Ron: Problem.
Laura: That's the eating bit I was talking about.
Ron: Yeah.
Ron: Fago to eat cytosis cells.
Laura: Those are my three.
Ron: Well, you said the same thing twice, so you'll only get one mark for that.
Ron: And the other thing you said was barricading them in.
Laura: Yeah.
Ron: To where?
Laura: A spot.
Laura: And then they smother them.
Ron: No, one mark for that, actually, because you touched upon some stuff, the lymph node library and the colorblind teletubbies.
Ron: But you didn't really say anything.
Laura: I did.
Ron: Laura, what was the first known inoculation vaccination?
Laura: Cowpox.
Laura: Cowpox.
Laura: It's more.
Ron: I just don't think you should be doing GCSE if you have, in the last five years, said the words moocao.
Laura: Yeah.
Ron: Moocow parks.
Laura: And the cow woman didn't get it because of the cows.
Laura: Was it small box from the cows?
Laura: Cowpox.
Laura: And then if you've had cowpox, you don't get smallpox.
Laura: Is it milkmaids?
Laura: Ron.
Laura: Ron, look up at me.
Laura: Run.
Laura: Run.
Laura: To understand how dying is that right?
Ron: You weren't very staffless in the middle of day.
Ron: Is it milkmaid?
Ron: MOOCs?
Ron: Yeah.
Ron: One more wooden.
Laura: It.
Ron: Could you just for three marks.
Ron: So do that information what you will.
Ron: How does vaccination work?
Laura: You inject a small amount of a pathogen that might be inactive or could be live into our body, but a small enough amount that your immune systems or your white blood cells can sort of easily learn it and conquer it.
Laura: So they learn the markers and they wipe it out and then they kind of have memory in the lymph nodes for what they fought and beaten before.
Laura: And so that means next time that pathogen enters the body, they know how to defeat it, even if it's in a bigger quantity.
Ron: I'm going to give you two and a half out of three.
Laura: Why did I drop a mark?
Ron: You dropped half a mark because it's not a very small amount.
Ron: What you do is you inject what you call either dead or what you call attenuated.
Laura: I said inactive.
Ron: Did you?
Laura: Yeah, I did say small amount, but I did say inactive.
Ron: I think I'm being fair with giving you half a mark for that point.
Laura: Okay.
Laura: Patreon.com Lexxeducation and sign up and tell him in a message.
Ron: Yeah, if you do that, we'll give you my mobile number and you can ring me.
Ron: Who was penicillin discovered by Laura and how?
Laura: ALexxander Fleming mouldy petri dishes, not on a sandwich.
Ron: Yes.
Ron: Another two Marks for Laura.
Ron: Laura for one mark.
Ron: True or false, antibiotics only work for bacteria and viruses, not for funguses.
Laura: Correct.
Ron: That is false.
Ron: Do not work for viruses.
Laura: D***.
Ron: Yeah.
Ron: Bit of a Treko, but not too much of a Treko.
Laura: Semi tricko.
Ron: Name two drugs Laura derived from plants.
Laura: Last question.
Laura: If I'm honest.
Ron: Well, it's not there's two more.
Laura: Oh, divide from far.
Laura: Plants.
Ron: I'm sorry, what was that?
Ron: Derived from farts.
Laura: I was trying to say plants.
Laura: And then I read my notes.
Laura: I remember saying, Aspirin comes from the bark of a willow tree.
Laura: Does that count as a drug?
Ron: It's almost side effect free.
Ron: Yeah, I'll give you that one.
Laura: And then the reason I said farms was because I started reading my notes and that says fox gloves.
Laura: They make digitalis for heart problems.
Ron: Yeah, that's another one.
Ron: Good reading, Laura.
Ron: Well, actually, bad reading, but good reading.
Laura: Bad.
Laura: Speaking whilst reading.
Ron: Yes, that's true.
Ron: And then for your final mark, Laura, the last one that we're doing is what's?
Ron: A double blind trial.
Laura: Double blind trial.
Laura: Is that one where you do a placebo on some people?
Ron: Yes.
Ron: Laurie, you've done stunningly well on this quiz.
Laura: Yes, I love praise for me.
Laura: Stick another praise in my feedbox, baby.
Ron: So that's for totals counting with Ron.
Ron: A two and a one and a one.
Ron: I'm not adding these.
Ron: 2346 and a half.
Ron: Ten and a half.
Ron: Eleven and a half.
Laura: Eleven and a half.
Laura: Pretty swish.
Laura: Stick that in the spread over Carol.
Laura: Yes, Ron.
Ron: I was playing with my tweezers again.
Laura: Ron.
Laura: All right, well, I love that for me.
Laura: Well done and goodbye forever.
Laura: Antibiotics.
Ron: Tell her.
Laura: All right.
Laura: Now, Ron, I'm going to be honest in the listen back, I didn't finish the episode.
Laura: The beginning, though, we were doing okay.
Laura: We were getting through that.
Laura: Did it end well?
Ron: It starts off strong.
Ron: I think it's some classic Lexx Ed content, to be honest.
Ron: It ends off us doing a weird sort of Top of the Pops rehash of a National Treasures episode.
Ron: Lots of stuff to talk through on the Socials this week.
Laura: Yes.
Laura: Also, I want to say, we mentioned that it's a video a lot in this episode.
Laura: Obviously it's not a video.
Laura: We did start practising with some video stuff.
Laura: We've decided to just keep videos for the patreon content, just due to time available to edit harder and paying for kids and having the time to be with kids.
Laura: Videos are going to be for everything that we record from now on for the patreon stuff.
Laura: But just yet, these will stay as audio only.
Ron: The first thing I want to mention on the social stuff is that last week, when we have recorded some influence content, I was not fishing for any kind of reaction from the listener.
Ron: I was genuinely just in a glass case of emotion.
Laura: I played that to Tom and he said, you cannot leave that in.
Laura: I know you two think it's funny, but it's just sad.
Laura: Please don't leave it in the edit.
Laura: And I said, I think our listeners will get it.
Laura: It'll be fine.
Ron: My name is Tom and I'm in touch with my feelings.
Ron: And I just want to say that it's always nice when we get interaction on social media and stuff and it does feel good with every like every reshare, every comment and stuff.
Ron: And we don't have time to reply to all of them, we don't have time to retweet everything.
Ron: But we do see it all.
Ron: And it all does leave a positive impact on us.
Ron: But the 36 hours after the Ron Appreciation post, I was very excited.
Ron: And my phone doesn't buzz or make a noise when it turns on for mind peace reasons, but every time I looked at Twitter, there was a genuine source of warmth in my heart and I want to thank everyone that contributed to that because it was lovely.
Laura: Ron, you're so mellow this week.
Laura: This might be the most wholesome intros and outros we've ever done.
Ron: Oh, it's because I'm very drunk.
Laura: Are you?
Ron: I'm quite drunk, yeah.
Laura: Oh, Ron, I'm so hungry.
Laura: I haven't had dinner yet.
Ron: I went on a hike today, which meant I didn't get to have lunch.
Ron: And then the hike ended at a brewery and then I went and then I didn't want to quite go home.
Ron: So then I had a beer on my own while waiting for waiting to meet someone.
Ron: I had a beer on my own while waiting to meet someone.
Ron: And then Laura, you you laura messaged me and we had plans to record and I was like, Whoa.
Ron: And hightailed it home so we could do this.
Ron: And I'm going to leave and go have some more beers after this.
Laura: I'm going to have some dinner.
Laura: Because it turns out, looking after a dog and a child on your own all day, you have very little time to take care of yourself.
Laura: So I'm going to put some food in me and hopefully feel a little bit more, I don't know, reasonable in a moment.
Laura: But what I thought I'd do, Ron, is because I needed to tell everybody about chart of the podcast, but I, like, you very uncomfortable with being the centre of attention once I've made myself the centre of attention.
Laura: So I've also gathered up everybody else's news from this week.
Laura: So, in place of a register, because you got drunk and didn't write one, we're going to quickly run through everybody's big announcements for things that they achieved this week.
Ron: I'll say their name.
Ron: You say what they did.
Ron: John.
Laura: I love it.
Laura: He weeded his patio.
Laura: Andrew went to his first barbecue of the year and lost its wingball to a dog.
Laura: Lucy gave someone a lift home from the pub, which was actually quite out of her comfort zone.
Laura: Legend.
Laura: Well done, Lucy.
Laura: Lawrence bought some Lego, and not in a personal sense, but because a d***.
Ron: Good teacher, Lawrence is undisclosed.
Laura: Oh, no.
Laura: Who was it?
Laura: Tom.
Laura: It was someone called Tom.
Laura: I've not copied his name.
Ron: Just doesn't happen.
Laura: Finished reading his second book for this calendar year.
Laura: Well done, Tom.
Ron: That is not bad.
Ron: I'm on the same quota.
Ron: Cheryl and Le figured out how to.
Laura: Operate their gas hob after quite some time.
Ron: Do you think they've just been ovening things, microwaving things, or do you think that gas has been leaking into their house?
Laura: I got the distinct impression and I'll double cheque the instagram.
Laura: I think it was instagram.
Laura: Finally got round to figuring out how to lower the flames on the gas hob after having it all too hot for over a year.
Ron: Wow.
Laura: Yeah.
Ron: Is this person's name Nicking Twitches?
Laura: Well, that's their instagram.
Laura: I didn't know if that was maybe Nicky.
Ron: Yeah, I didn't know if that was yeah, I was going to say, oh.
Laura: I think it is Nicky.
Ron: I've clicked Nicky Twitches.
Laura: Nicky.
Ron: Nicky Twitch.
Laura: I think I'd get on with Nikki because it's a rainbow made of cat paws.
Laura: And this is another thing I love in terms of people getting in touch.
Laura: I think this is the first time Nikki's commented on anything.
Laura: And I love that when a new person just suddenly joins in and I'm like, yeah, it's a new rat.
Ron: My favourite one is when a different post goes round and then people that don't follow, don't follow either of us comment and you're like, well, you're clearly not a listener, because you'd probably have followed if you were and keen enough to interact, but you've just decided to f****** pile on in some positive discourse.
Ron: I appreciate those people as well.
Ron: Abby Rose.
Laura: Oh, no, sorry.
Laura: Nikki got rid of a coffee table.
Laura: Nikki actually did loads of stuff.
Laura: Nikki got rid of a coffee table and had a pint of Guinness and bought a pair instead of a bag of crisps.
Laura: Just a smashing week for Nikki, really.
Ron: Abby Rose.
Laura: It's Abby Rose's birthday.
Laura: You remember Abby rose she's agony dad's favourite chandler.
Laura: So everybody sort of take a bite of a metaphorical donut, because she said if we were in an office, I suppose abby Rose, you just have to leave some donuts in the patreon discussion because that's the lab rat lounge.
Ron: Yes.
Ron: Happy birthday to Abby rose and a different Abbey.
Laura: A different Abbey managed to do a workout whilst very hungover.
Laura: So that's your challenge for tomorrow, Ron.
Ron: Absolutely not.
Ron: And finally, last but not least, certainly Colin.
Laura: Colin did the job that we all put off and cleared just a load of tat off the dining room table so they could eat on the table.
Laura: How many times have you gone months without doing that, Laura?
Ron: I am 27.
Ron: I don't have a dining room table.
Laura: But you have a table.
Ron: I've got a table, yes.
Ron: I don't have so many tables.
Ron: I don't have so many tables that they have to be labelled.
Ron: I don't have label tables.
Ron: I've got a table.
Laura: I only have one table.
Laura: But it's still in the dining room.
Ron: Yeah, I know, because you live like a cool drifter and that's fine, but I spend all my time at home, so my table is a table.
Laura: But is it tidy enough to eat off?
Ron: Yeah, you could eat your dinner off of it.
Laura: It's as if it was a dining table.
Laura: All right, we'll let you go now.
Laura: These have been some long intro outros, but, hey, we're giddy, we're excited, there's a chance podcast and we can tell you about it now.
Laura: Yay.
Ron: Class dismissed, everybody.
Laura: Class dismissed.
Ron: Class bloody dismissed.
Laura: Class beautifully dismissed.
Ron: I'm you know why?
Laura: Because I'm a mother, you know?
Ron: Class is not dismissed, class is ongoing and class is positive and class will see you next week.
Laura: Bye.
