High Tummy Pressure

Laura: Hello and welcome to another episode of Lex Education, the comedy science podcast where comedian me, Laura Lexx tries to learn science from Ron.

Ron: Hello, I'm Ron.

Laura: Hi, Ron.

Ron: How's it going, Laura?

Laura: Oh, you know, just loving my life.

Ron: You just got back from two weeks in Greece.

Laura: I had a lovely holiday, except for a very weird incident.

Laura: Do you want to hear about a weird incident?

Ron: Is this the olive press tour or the plane or?

Ron: No, the cat p*** luge?

Laura: No.

Laura: Right.

Laura: Where would you say it's the creepiest part on a person's body to kiss a stranger?

Ron: Back of the knee.

Laura: Oh, yeah.

Laura: That is creepy.

Laura: I got kissed by a creep just on my upper arm, like, between elbow and shoulder, just a little smacker on my bicep.

Ron: Context.

Laura: The context is weird.

Laura: Me and Tom are exploring some ruins up in Crete and then we turn around a corner and there's a creek.

Laura: Little dude sitting on a rock who's like in Greek Accent I won't do it.

Laura: Have you seen the Roman sisters over here?

Laura: And we're like, oh, no.

Laura: So we go over and have a look.

Laura: Creepy dude is showing us and we're like, oh, who's this man that just sits on a rock showing people where the Roman cisterns are?

Laura: And we're like, fine.

Laura: And then he gets quite insistently talking to us.

Laura: Well, me, because Tom's, like, striding away, but I'm there trying to be, like, super polite, like, don't upset a slightly strange person.

Laura: And then he asks if we can take a photo together.

Laura: And I'm like, oh, this man smells horrendous.

Laura: I don't want to get near him, but he wants me to take the photo on my phone so he doesn't benefit from the photo in any way.

Laura: So I was like, yeah, sure, I'll take a photo.

Laura: Took a photo together, and then he just kissed me on the upper arm.

Ron: Yes.

Ron: No fan of that.

Laura: That's weird, isn't it?

Ron: That is weird.

Laura: It's such a soft part of the body to get kissed on by a weirdie.

Ron: Yeah, and he's really engineered that.

Ron: And presumably he wasn't shorter than you.

Laura: He was ron.

Laura: He was.

Ron: That was just lip height for him.

Laura: Well, I think he was crouching a little bit as per a man that sits on a rock and shows people some ruins.

Laura: Like, now, I want a review.

Laura: Was real.

Ron: Sorry to backtrack slightly, but I can't get this out of my head.

Ron: What's, the cistern in a romance, it's surely not the back part of a toilet.

Laura: No.

Laura: So it was like a huge like a layer of a multistory car park.

Ron: Yeah.

Ron: So a big square space.

Laura: But with, like, big, very square columns in it, cut into a rocky cliff up on the top of this mountain where these ruins were.

Laura: And I guess it was for them to store water or just keep things cool.

Laura: Don't really know.

Ron: Okay, I've known you for a long time.

Ron: Now, I presume you thanked him, took the photo and walked away.

Laura: Well, yeah, I avoid conflict at pretty much all costs, so I did walk away.

Laura: And then I said to Tom I really hated that.

Laura: That really creeped me out.

Laura: I didn't like that.

Laura: And he went, Why are we being so nice to him then?

Laura: And I was like, I don't know, I think that's just my default so they don't get angry and start screaming at me.

Ron: Yeah.

Laura: What would you have done?

Ron: I don't think I'd have said anything.

Ron: I would have probably jumped away and made it very clear that that was bad.

Laura: Like a cartoon.

Ron: Yeah, because I do that.

Ron: No.

Ron: When a close friend gently touch me on the shoulder, I'll jump halfway across the room.

Ron: So I think an old sister ruined man kissing me tenderly on the bingo wing would cause distress.

Ron: I probably wouldn't say anything.

Laura: Yeah, it was weird.

Laura: Other than that, though, lovely holiday.

Ron: Nice.

Ron: That's very nice.

Laura: How have you been?

Laura: Have you been all right?

Ron: Yeah, I'm good.

Ron: I'm just very boring.

Ron: I just got a lot of work on at the moment.

Laura: No, you're such a grown up.

Laura: Anyway, listen, it's a good episode today and it's a bit long, so we probably shouldn't have told that whole story about assistant man Ron.

Laura: Lots of people are very worried that you're dead.

Laura: Would you like to address claims and prove that you're alive?

Ron: No, I would like to spend the next couple of months sowing Seeds of Doubt playing backwards clips of cryptic clues, introducing another character, maybe using the album art to insinuate my death.

Laura: You are on any of the album art, to be fair.

Ron: Yeah, but I think, like, a picture of me boiled or something, and then let's do a wrong look like competition somewhere and we'll find an orphan that can be me.

Laura: Oh, you are a strange guy.

Laura: Whether you're alive or not.

Laura: The Heat has done interesting things to that noggin of yours.

Laura: Thank you.

Laura: We've got a lot to catch up on in terms of the social media.

Laura: We've said thank you a lot just on social media.

Laura: But special shout out this week to Emma on Instagram, who sent us a lovely message about having found the podcast and binged it all and then having to cope with the slow drip of weekly episodes now.

Laura: Yeah, sorry about that.

Laura: We simply can't put more out because we don't have time.

Laura: It takes a lot of effort putting it out, doesn't it?

Laura: Ron, who had to do the socials and now appreciates how much hard work I put into this.

Laura: Yes, I can't learn science, but I am good at Twitter.

Laura: And also, Emily L is bingeing and not caught up yet.

Laura: But, Emily, I wanted to leave this as a hello and a nice surprise for when you get here.

Laura: If anyone else is bingeing and not caught up, hey, let us know.

Laura: We'll always say hi from the future to you in the past, but you're listening in the future.

Laura: What?

Ron: Probably not the forum, Laura, but friend of the podcast Danny messaged the podcast on Instagram, but it was meant for you.

Ron: But I did reply and I said, hey, Laura's on holiday, but you should probably catch that up.

Ron: Hey, Danny.

Laura: Also from Twitter, there's a cool animated periodic table that we did retweet, but I've also put a link to it in the show notes.

Laura: So have a listen to that.

Laura: Have a listen to that.

Laura: Have a look at that.

Laura: It's like a cool like all of the elements have been animated with how full the rings are and what's on them and stuff.

Laura: So that's good.

Laura: CG figures.

Laura: Shout out to them.

Laura: It was cool.

Ron: Yeah, it was cool.

Laura: Yeah.

Laura: And also my final note before you listen to the episode, my topical comedy was correct at the time of recording.

Ron: Yes.

Laura: Enjoy.

Ron: Hello, Laura.

Laura: Hi, Ron.

Ron: How are you?

Laura: Do you know what?

Laura: I'm a bit dopey in days today and I'm thirsty.

Laura: What do you mean?

Ron: Great.

Ron: Segway, do you remember what we are talking about last week?

Ron: Last biology.

Ron: Last biology?

Laura: No.

Laura: No way.

Laura: No, I remembered last week, though.

Laura: Renewable energy.

Ron: Yes.

Ron: You just asked for the quiz.

Ron: No, last biology lesson.

Ron: We were talking about diffusion.

Laura: Oh, yeah.

Ron: You weren't a fan.

Laura: Lungs.

Laura: And the nephron.

Ron: Oh, the nephron.

Ron: You do love the nephron.

Laura: I do love the nephron.

Laura: It's a good thing.

Ron: That means we did this before your walk.

Laura: Yeah.

Ron: That feels like ages ago.

Laura: It was three weeks ago, so that makes sense.

Ron: So can you just briefly explain what diffusion is?

Ron: Because it's going to come up.

Laura: It's chaos theory.

Ron: Yes.

Laura: Jurassic park.

Laura: Dinosaurs.

Ron: No.

Laura: Yes.

Ron: No.

Laura: Yes.

Laura: You said you said it was dinosaurs explained chaos theory.

Ron: You did not say diffusion is dinosaurs.

Laura: You said jeff Goldblum tells us about it in Jurassic Park.

Ron: Yeah.

Laura: I'm just remembering.

Laura: Thanks.

Laura: I haven't finished.

Laura: Fusion is when all the we need to be in the clean water.

Laura: And then when something with loads of stuff in it is next to something with no stuff in it, the stuff wants to spread out a bit.

Ron: Yeah.

Laura: Just goes in there to get as much space chaotically and randomly as much percentage as possible of likelihood.

Laura: So what are the chances it wouldn't.

Ron: That is diffusion explained like a lobotomy victim.

Ron: But the premise is fair.

Laura: Like a lobotomy victim.

Ron: You know, all of the words were a bit off.

Laura: Why?

Ron: And it was just a bit convoluted.

Ron: But no, the premise was right.

Laura: Don't praise in such damning fashion, please.

Laura: I got it right.

Laura: So just say, well done, Laura, because.

Ron: If I'm not going to praise in damning fashion, then you're not going to get praised.

Laura: Okay.

Laura: Hello, good sir.

Laura: Diffusion is where there is immense saturation in one solution and then that solution travels by the by a solution with a lower percentage of stuff in it and the stuff seeps through a membrane.

Laura: Goodbye, language.

Ron: You sound like Charlie from always Funny trying to do bird law.

Ron: Yes.

Ron: All you needed to say was it's the movement of particles down a concentration gradient.

Ron: Insolution.

Laura: I think if you listen back to the recording, that is pretty much what I've said.

Ron: Yeah.

Ron: And if I kind of chiselled it down in some kind of DaVinci codesque way, like linking it with red bits of string on my able to distil that from that.

Ron: How are we still talking about a concept we covered last week?

Laura: You brought it up.

Ron: Yeah, but I just wanted to think that one thing and then we could move on.

Laura: Well, I did.

Ron: Right, okay.

Laura: If you were for Nicotine, then it wouldn't take five minutes, would it?

Laura: You just listen and understand and then we could move on.

Ron: If you just accepted my back handed compliment and moved on.

Laura: Well, how am I supposed to feel good about myself if your back hands are always compliments?

Laura: I think we should please.

Ron: Okay, let's dive into what we're doing today.

Laura: Why can't that be a byproduct that I feel good about myself for once?

Ron: Because of your f****** brain chemistry?

Ron: Do you want to know what we're doing today?

Laura: I don't know now because I was already in a floopy mood and now you made me feel even grubbier.

Ron: I thought it was really good.

Laura: I was just putting it don't use that tone.

Laura: Just move on.

Laura: Yes, please.

Laura: Ron, I'd love to know what we're doing today.

Ron: Good for the way that you explained it.

Ron: Is that kind that's funny.

Ron: Today we're covering osmosis.

Ron: Do you know what that is?

Ron: You named a cartoon and then you said out the window.

Laura: I thought you said something else.

Laura: Do I know what mosus is?

Ron: Yes.

Laura: I can turn the volume down on my headphones.

Laura: Can't he?

Laura: Can he?

Laura: That's like seeping through stuff, isn't it?

Laura: Like when you say, like, I learned that by osmosis.

Laura: It just went in while you were asleep.

Ron: That's how it's commonly used.

Ron: Yes, but that's not what it is in sort of biology.

Laura: Why don't they just use it like everything else does?

Ron: Because people have taken it from the biology and then they're wrongly applying it to other situations.

Ron: I don't think scientists back in the day were reappropriating random words.

Laura: So is it not like stuff just seeping in of its own accord, then?

Ron: Yes, but not anything.

Ron: It's specifically the movement of water across a membrane.

Laura: F***.

Laura: It's always f****** membranes, isn't it?

Ron: In biology it often is, yes.

Ron: So you remember last time when we're doing diffusion, particles were moving from a high concentration gradient to a low concentration gradient?

Laura: Yeah.

Ron: Osmosis is the process of water that doing the opposite of that.

Laura: P*** off.

Laura: Why is it the opposite?

Laura: Why don't they just all do the same thing?

Ron: Because if you think about it.

Laura: If I think about it, I do.

Ron: Think carry on thinking about it.

Ron: So when we're talking about something in solution, we're talking about it being dissolved in water, right?

Laura: Probably.

Ron: So when those particles are moving from high concentration to low concentration, it makes sense that water would do the opposite because they're suspended in the water.

Laura: Right.

Laura: Hang on.

Laura: I've got some salty water in one cell.

Ron: Yeah.

Laura: I've got some just normal water in the other cell.

Laura: And then they've got a sensation division.

Ron: Was it called concentration gradient?

Laura: That's it.

Laura: They've got that.

Laura: So the salt goes through the membrane into the other cell.

Laura: Why would the water go the other way?

Ron: So when you talk about osmosis, is.

Laura: The water not like the salt?

Ron: So mostly this happens across membranes where the particle insolution isn't going through the membrane.

Laura: Where is that going then?

Ron: Well, it's just staying on that side of the membrane.

Ron: So you just have one cell that is saltier than the other one in this example.

Laura: Right.

Laura: And then what the water's like?

Laura: Oh, that poor cell has got too much salt.

Laura: We should go and help.

Ron: Well, it gets a bit sucked in.

Ron: Yeah.

Ron: So do you want to know the sort of the physics of why this happens?

Laura: I feel really crossed and I don't really want to learn anything.

Ron: Well, just imagine it's a bit like when it's a bit like, let's just keep talking about it and you'll hear some ways where it comes up.

Ron: And then if you want to learn why this happens, we can, but you don't have to because it's not in the syllabus.

Ron: But I knew you'd ask how I did the research.

Laura: Okay.

Ron: So this process of water moving to the place with a higher concentration gradient, there are a few places in day to day life where this happens that you might know.

Laura: When you're in bed in a tent and it's raining and your leg touches the side, it lets the water through.

Laura: There are more people on the inside of the tent than the outside on your pitch.

Laura: So that is a higher sensation gradient than in the outside.

Ron: No, but okay.

Ron: Have you ever salted an obergine?

Ron: Laura.

Laura: Podcast is for children.

Laura: Pleasantly.

Laura: How?

Laura: Hurry.

Laura: I found some water.

Laura: It's quite old.

Laura: I'm not going to drink it.

Laura: Salt is an aubergine.

Laura: Yeah, I guess so.

Ron: Have you?

Laura: Yeah, I've put salt on an ovogene before.

Laura: I've never thought to myself at the time, I'm doing an activity called salting an ovgine, but everything I eat is covered in salt and I like to eat ovgine.

Ron: But I mean, have you ever salted an ovarine before you've cooked it to get all the water out?

Laura: No.

Laura: What about how have you never done that?

Laura: Why would you get all the water?

Ron: You cut it into slices, then you salt it, you leave it on some kitchen roll, and then it's nicer when you eat it.

Laura: Is it?

Ron: Yeah, it gets rid of, like, that rubberiness.

Laura: I love that rubberiness.

Laura: It feels like you're eating something naughty.

Laura: It feels like you're eating packing beans.

Laura: I love obergines.

Laura: I actually think obergines are like a prank.

Laura: They're so different to all other natural foods that you're like.

Laura: Are you actually real?

Laura: What are you?

Ron: That's how I feel about bananas.

Ron: Sometimes bananas just seem op.

Laura: Yeah.

Laura: What are you, then?

Laura: Eh?

Laura: You all right?

Laura: Are you magic?

Laura: Who's put you up?

Ron: Although I don't like obergin enough to agree with you, but I do think that they're really different.

Laura: I cut myself on an obergine once.

Ron: What?

Laura: Yeah.

Laura: I'd cooked an aubergine and the skin had gone sharp.

Laura: It sliced my finger open.

Laura: He wouldn't think an oberging could do that to a person.

Ron: God, if Darwin could see us anyway, I thought that would be a universal thing, salting over sheets.

Laura: Another one on red wine.

Laura: When I've spilt it on the carpet.

Ron: That'S not really the same thing.

Ron: Another one that comes up.

Ron: This is why salt kills tomatoes.

Ron: That is the same thing, you see, that brings all the liquid out.

Laura: No, it brings the flavour out.

Ron: Yeah, but you notice that if you sold them, there'll be more juice.

Laura: I've never noticed that.

Ron: This is the same reason why salt kills slugs and snails.

Laura: Oh, no.

Ron: Yeah, because it's a very thin membrane on their skin.

Ron: They don't have, like, a protective skin layer like we do.

Ron: That's why they have to cover themselves in slime.

Ron: Oh, my God.

Ron: Ignoring that.

Ron: If they run into salt, actually half lost one, it's still ignoring that.

Ron: I'm going to look at it through my water bottle like a basilisk.

Laura: Not saying anything wrong.

Ron: Yeah, because it makes it easier to edit the sound.

Ron: And finally, it's by this process that salt causes high blood pressure.

Ron: Can you think how that happens?

Laura: Well, the slug is furious about the fact that you're killing it, so it's really angry.

Laura: Are we still talking about slugs?

Ron: People.

Laura: People, yeah.

Ron: How does it cause high blood pressure in people?

Laura: If you're putting that much salt even on obergens, you've probably got too much salt in your blood.

Ron: Yes, but how does it cause the high blood pressure?

Ron: Whether is there a lot of it.

Laura: Or not, it's salts in your veins and the blood can't get through.

Ron: Think it through using information that you've been given today.

Ron: Don't just say something.

Laura: Does salt get out of you?

Laura: No, the water gets out of you.

Laura: Water sucks out your skin.

Ron: Why would it do that?

Laura: Because that's what you said happened to oviens and slugs.

Ron: But you're not rubbing yourself in salt, are you?

Laura: That does if you spend a lot.

Ron: Of time in the sea shouting, bath.

Ron: So, Sammy, if you spend a lot of time in the sea, your skin.

Laura: Does dry out and then you get high blood pressure.

Ron: No.

Ron: When you eat salt, how do you get high blood pressure.

Laura: All the water goes into your tummy.

Ron: Then you have high tummy pressure.

Ron: But that's not what we're talking about.

Laura: All the water gets in your blood.

Ron: Yes.

Ron: So you eat lots of salt.

Ron: Then there's lots of salt in your blood.

Ron: So then the water virosis goes into your blood, and then you have a higher volume of blood, and then you get high blood pressure.

Laura: So it's like a high diluted blood.

Laura: That's what blood pressure is?

Ron: Yes.

Ron: It's very wet blood.

Laura: Why does water love salt so much?

Laura: So, really, we need to cure osmosis, and then we could have as much salt as we wanted.

Laura: Delicious, delicious salt.

Ron: Now we're about to finish on osmosis.

Ron: Do you want to know why it happened already?

Ron: Yeah, that's it.

Ron: It's not a difficult concept.

Laura: Right.

Ron: Do you want to know how it works or no, not bothered.

Laura: I feel like you want to tell me.

Ron: I vehemently don't.

Laura: Then yes, please.

Laura: I'd like to know.

Ron: In the same way that when things diffuse, all the particles are just moving around freely and randomly.

Laura: Chaos theory.

Laura: Like a dinosaur.

Ron: Yes.

Ron: And then you remember that they moved, they spread out, because when more of them are on one side, there's more.

Laura: Percentages of them being on the other side.

Ron: Yes.

Ron: So there's a higher chance that they're going to move that way.

Ron: Okay.

Ron: They're going to move into the empty space just by probability.

Ron: Yeah.

Laura: Remember that probability?

Laura: I said that.

Laura: I do remember it.

Laura: I'm saying it.

Ron: Water is doing the same thing.

Ron: It's sort of freely moving around.

Ron: Okay.

Laura: Yeah.

Ron: What are you doing?

Laura: I've got to cut a bit of skin off my foot.

Ron: That's foul.

Laura: Don't ask Ben.

Laura: If you don't want to know, don't.

Ron: Do it while we're working.

Laura: It was getting stuck in the carpet.

Ron: Foul.

Ron: So water is doing the same thing.

Ron: Why can't we just go, oh, my God.

Ron: It's going to be the same thing that you interrupt me before I f****** explain it.

Laura: But if it's the same, it's the same.

Laura: Doesn't need a different name.

Laura: It's just water diffusion.

Ron: Let me finish this horrible troll.

Ron: So water is doing the same thing okay.

Ron: Where it's moving around freely, but when something is dissolved in water, the water interacts with it slightly, and then that means that that water is not moving around freely.

Ron: It's interacting with the thing that's dissolved in it.

Ron: So when there's a higher concentration on one side of the membrane, there's a net movement of water to that side until the concentrations are equal.

Ron: Do you understand?

Laura: Yes.

Ron: Okay, cool.

Ron: The last thing that you need to know is that osmosis is a passive process, so it doesn't take any energy.

Ron: Like diffusion.

Laura: Brilliant.

Ron: Okay.

Ron: Next we're going to learn about active transport.

Laura: Next thing, you need to apologise for giving me a troll.

Ron: Because next thing I know, you're going to be cutting off more skin flaps and interrupting me again.

Laura: I'm not going to say anything for the rest of the podcast.

Ron: Okay?

Ron: Neither am I.

Ron: I'll apologise for calling you a troll if you apologise for interrupting me so much.

Laura: I'm trying to learn, Ron.

Laura: How do I learn otherwise?

Ron: Don't interrupt Ronnie Harvey to explaining something, asking about it, or complaining about it.

Laura: Okay?

Laura: I'm sorry I interrupt so much, Ron.

Ron: I'm sorry I caught you a troll, Laura.

Ron: So now we're going to learn about active transport.

Ron: Okay?

Laura: Like a finger buff.

Ron: I saw that on Twitter.

Ron: Didn't get it.

Ron: Don't get it now.

Laura: What do you mean?

Ron: What's?

Ron: The venga bus.

Laura: What?

Laura: What do you mean you saw it on Twitter?

Laura: You saw the venga bus?

Ron: What do you mean someone tweeted about a venga bus?

Laura: You don't know what the Venga bus is?

Laura: The Vanguard bus is coming and everybody's.

Ron: I've heard of the Vanguard.

Laura: San Francisco and into city disco.

Laura: The wheels are still alternate and traffic lights are burning.

Laura: So if you like to party, come on and move your body.

Laura: Yes.

Laura: By the Venga boys.

Laura: The venga, boss.

Ron: Oh, I've heard of the Venga boys.

Ron: I've never heard of the Venga bus before.

Laura: The venga bus is coming.

Laura: We like to party.

Laura: We like to party.

Laura: We like to party.

Laura: Oh, we're going to a pizza.

Ron: I know that one.

Laura: Oh, back to the island.

Laura: That's the Vanguard boys.

Ron: I like that one.

Laura: The Vanguard.

Ron: I remember that from school discos.

Laura: It's got Sound of Bus noises in it.

Ron: Anyway, so active transport, so diffusion and osmosis, there are two other processes that we've learned about moving stuff.

Ron: Those are obviously passive processes.

Ron: Don't take any energy from the organism that's doing it.

Ron: Whereas active transport is a way that cells can control what is going where by essentially pumping things across membranes.

Ron: Okay.

Laura: Like a little home office.

Ron: Sure, yeah.

Laura: Hello.

Laura: I'm the pretty Patel of the sell.

Laura: Pretty Patel.

Laura: And I'm in charge of what comes in and out of this cell.

Ron: Good.

Laura: The Labour Party just want all movement to be passive.

Laura: But in order to have the best Britain we can have, hit needs, adjust, people with money.

Laura: Thank you.

Laura: Goodbye.

Ron: Mandarin.

Ron: Right.

Ron: Active transport essentially proteins.

Ron: There are proteins that can be in the membranes of cells and they act like pumps.

Ron: So when the thing that they work for is at the same time who.

Laura: Do you work for?

Ron: When the thing that they work for is there?

Ron: They can swoop it through, basically up a concentration gradient.

Ron: Okay.

Laura: Oh, you know my mate Barry.

Laura: I'll let you through then.

Laura: Thanks.

Laura: Pretty pacel.

Laura: I really appreciate it.

Ron: There's active transport of ions and the roots of plants when they're getting stuff out of the soil.

Ron: And there's also active transport of sugar molecules in cells for respiration purposes.

Laura: I am the trunk of a tree.

Laura: I'm just letting all of the ions go up the tree, like the M two boop.

Laura: Operation Stack.

Laura: We've got a backlog of ions going up to the leaves to make juicy, juicy Fruit for me to eat.

Laura: Is that okay?

Laura: I understood that students should be able to that's me.

Ron: Describe how substances are transported into and out of sales by diffusion, osmosis and active transport and explain the differences between the three processes.

Ron: So very succinctly.

Ron: Can you just do that?

Laura: Diffusion is when all the bibs in one stuff is too much near an empty pool of water and they just gently mush across.

Laura: Osmosis is when the water chases the salt into another place.

Laura: And active transport is pumping things, protons, across stuff.

Laura: Ions in a tree.

Ron: Yeah, close enough.

Ron: All right, let's move on.

Laura: What did I get wrong?

Ron: Nothing.

Ron: Just perfect.

Laura: She said distinctly, so I didn't give you all the details.

Ron: It's perfect.

Laura: Yeah, but I know you don't mean it because you can't shake your head while you're saying, yeah, that was perfect.

Laura: That isn't how people look when they're describing perfect.

Ron: Shake my head.

Ron: This is the podcast.

Laura: I can see you.

Ron: Yeah, but the listener can't.

Laura: Well, I'm telling them he shook his head, but it was fine.

Ron: Yeah, it's good.

Ron: Let's move on.

Ron: Right.

Laura: I'm very mad at you.

Ron: I'm going to be mad at myself, too.

Ron: Right, so the next thing, it just wants us to run through this again.

Ron: We've already done this before.

Laura: F****** h***.

Laura: Never ends.

Laura: Does it once and they just go and just do it again.

Ron: Can you remember the different.

Laura: This is such an angry episode.

Laura: Why are you so furious with me?

Laura: I'm trying.

Ron: You're not really trying.

Laura: What have I not tried?

Ron: You just keep singing.

Laura: That's how I learn things wrong.

Laura: That's how I learn.

Ron: You did a long, pretty patel bit.

Laura: But I've remembered that now.

Laura: Pretty patel.

Laura: She does the active transport.

Laura: Hello.

Laura: Are you a protein?

Laura: You will be very helpful to the economy of our body.

Laura: Come inside, please.

Laura: Move to Manchester.

Laura: We've got some redistribution to do because the spitting can't be in London.

Laura: Then in a plant, the ions come in through the roots and then they drive down the M two all the way to the petals.

Ron: I take it all back.

Ron: I'm very sorry.

Ron: I'm sorry for calling you a troll.

Ron: Okay.

Ron: It just wants us to go through very quickly.

Ron: Cells make up tissues, tissues make up organs.

Ron: Organs make up an organism.

Ron: Okay.

Laura: Yes.

Ron: Remember when we did that before?

Laura: No.

Laura: But I'm glad you've reminded me.

Laura: So I'll write that down now.

Ron: Okay.

Ron: Do you want to just fire that one back at me?

Laura: Yes.

Laura: And cells make tissues.

Laura: Tissues make organs, and organs give you an organism.

Ron: Yes.

Laura: When you're in a cell on your own, you get quite bored.

Laura: You have to have a little w***.

Laura: You need a tissue.

Laura: What are you wanking with?

Laura: Your organ.

Laura: That feels nice.

Laura: An organism.

Laura: That's how I'll remember that.

Ron: Right.

Ron: That seems a lot more labour than just remembering four things.

Laura: Well how would you remember that just without it meaning anything?

Ron: Well, I know what a sell is.

Ron: I can picture that being at the bottom.

Ron: I know what an organ is and I know what an organism is.

Ron: So I guess I only have to really remember what a tissue is and so I just do that and then I move on.

Laura: Well, the Lord works in mysterious ways and in this analogy I'm the Lord.

Ron: So we're going to learn about a specific set of organs.

Ron: Now we're going to learn about the human digestive system.

Laura: Poop tube.

Ron: Poop tube.

Ron: The digestive system is an example of an organ system in which several organisms work together to digest and absorb food.

Ron: How many organs can you name involved in the digestive system?

Ron: Laura?

Laura: Small intestine.

Laura: That takes the water out of the food.

Ron: No, that was the large intestine.

Laura: I've been telling everyone that fast.

Ron: If the small intestine did it, it would be super dry before it got to the large intestine.

Laura: The small intestine do takes the food.

Ron: Out of the poo.

Laura: Small intestine though.

Ron: Yeah, that's one.

Laura: Large intestine.

Ron: Yes.

Laura: Bowel.

Ron: It's kind of a general word for intestines to be honest.

Ron: Were you under the impression that the bowels were something else?

Ron: Like your bowels?

Laura: Yeah, maybe that was a thing like a big kidney or something.

Ron: Sorry.

Laura: I guess your stomach.

Ron: Yes.

Laura: Kidneys?

Ron: No, not part of digesting.

Ron: We know what those kidneys do.

Ron: We did that before.

Ron: Is your friend of mine the nephron?

Laura: But we is kind of like poo, isn't it?

Ron: I don't know whether it's not digesting as it's cleaning the blood.

Ron: That's okay, you can say no, we can stop there.

Laura: I don't want to.

Laura: I'm still thinking.

Laura: Are there more?

Ron: I can think of two.

Laura: Okay, it goes on my tummy.

Laura: Pancreas?

Ron: No.

Laura: Sphincter.

Ron: Not an organ, but it is involved.

Laura: Heart?

Ron: No.

Laura: Lungs?

Ron: No.

Ron: Think about it.

Ron: Don't start just naming.

Laura: Gallbladder.

Ron: Yes.

Laura: Wicked.

Laura: You can have that removed.

Laura: So it can't be that important.

Ron: We'll talk about the callback later actually.

Ron: And I've actually got a suggested analogy for you for that.

Laura: New feature on the podcast.

Laura: Ron.

Laura: Suggested analogy?

Ron: Yeah.

Ron: More and more I try and lean into your madness just to see if it helps things stick.

Ron: So today we're going to learn about.

Laura: What was the last one?

Ron: Oh, the colon.

Laura: I said bomho, you said sphincter.

Laura: What's the difference?

Ron: We've said three different things.

Ron: So that should be a queen.

Ron: The sphincter is a muscular ring and actually you have I think like seven or something sphincters in your body.

Ron: That's not your only one.

Ron: What you're actually talking about is the a*** and then the colon is the six inch bit between the a*** and the large intestine.

Ron: You're laughing at the word a***?

Laura: Yeah, funny word.

Ron: Okay, so we're going to learn about enzymes now and no, not the boy band with just timberlake.

Laura: Seven.

Laura: Of my sphincters just tightened when you.

Ron: Said that, but you might remember it now.

Laura: Hey, Tom, do you know you got seven sphincters?

Ron: What?

Laura: Tom's bringing me a cup of tea.

Laura: This is all this nonsense science, Ron.

Laura: Makes me learn.

Laura: You got seven bummers, mate.

Ron: I think it's seven bumbles.

Laura: What?

Laura: How do you know?

Laura: A sphin?

Laura: Dew is in a bum hole type.

Ron: Isn'T it.

Laura: Him, Ron?

Ron: Yeah, I've Googled this.

Ron: They're actually 50 or 60 different 50 or 60 different?

Ron: Different types of sphincters.

Ron: So there must be loads more than that.

Laura: It's just littered with balls.

Ron: But then this one's saying, what are the five sphincters in your body?

Laura: Two eyeballs, a bomb hole mouth, one of your ears.

Ron: Then this one is saying, what are the six sphincters of the digestive tract?

Laura: Hi, John.

Laura: Thanks for the tea.

Ron: So, yeah, you are riddled with bomb holes.

Laura: Whoa.

Laura: 90% bomb hole.

Laura: That's the name of my next edible brochure.

Ron: Anyway.

Laura: When someone calls you an a******, you're like percentage wise.

Laura: Yes, mate, I am at least 5% article.

Ron: I'm actually a multitude of arthritis.

Ron: Anyhow.

Ron: Right.

Ron: We're learning about enzyme.

Ron: Do you know what an enzyme is?

Laura: No.

Ron: Enzymes are biological catalysts.

Ron: Do you know what a catalyst is?

Laura: Catalyst is a thing that helps another thing happen.

Ron: Yep, absolutely.

Ron: So catalysts are something that speed up a reaction.

Laura: It's a wine mixer.

Ron: Crucially without being used up themselves in the process.

Laura: Crucially.

Ron: That's the difference.

Ron: Struggling to focus today on no f****** s***.

Laura: Why there's no s***?

Laura: Because all 50s are on lock.

Ron: So why that's crucial?

Ron: That's the difference between a catalyst and an accelerant or something.

Laura: What is?

Laura: What?

Laura: I've missed a big part.

Ron: The fact that the cashless doesn't get used up in the process of the reaction.

Laura: Just doesn't give of itself.

Laura: No, it just provides a place for it to happen.

Ron: Exactly.

Ron: Yeah.

Laura: It's just a location.

Laura: The Catalina Wine Mixer still survives.

Ron: It speeds up business, but Catalina is not used up in the process.

Laura: All right, that's a good way to remember that.

Laura: Do you know a bit I'm doing?

Ron: Are you doing the portivolar?

Laura: Yeah.

Laura: Such a good film.

Ron: Lumberjack, specifically how enzymes work is quite complex, but the simplified method that we need to learn about is called the lock and key method.

Laura: Okay, lock and key.

Ron: So each enzyme will have a specific reaction that it catalyses.

Ron: Right, okay.

Ron: Jesus Christ.

Laura: Okay.

Laura: What's an enzyme?

Ron: The biological catalyst.

Laura: An enzyme is a biological are they in washing powder?

Ron: Sometimes, yes.

Ron: In bio washing powder.

Ron: They used to take them from cows.

Laura: So an enzyme is a Catalina.

Ron: It's a catalyst.

Laura: Yeah, I know, but I'm trying to make notes so that it makes sense and then enzyme you only do one type of business at an enzyme.

Ron: Broadly.

Ron: You don't go they have specific ones.

Ron: Yeah.

Laura: Each enzyme is its own different trade.

Laura: Fair.

Ron: Yes.

Ron: That's a good way of putting it.

Laura: All right.

Ron: Enzymes are globular proteins.

Ron: Okay.

Laura: Globular.

Laura: Yes, I'm here for that word, globular.

Ron: So there are different types of protein.

Ron: There are globular ones and there are fibrous ones.

Laura: That's not an actual science word, is it?

Laura: Globular like a global.

Laura: Sounds like what's a face in that thing.

Laura: Karen Gillen.

Laura: Sounds like her in Marvel Lobby in Santorino or whatever they were called.

Ron: I have no idea.

Laura: Where's Tom when you need him?

Ron: Shout for him, he'll get it.

Laura: I'll ring him.

Laura: Alright, hang on, hang on.

Laura: I'll sort this.

Ron: Bye.

Laura: Hi, Tom.

Laura: What do I mean when I say Karen Gillen in that thing?

Laura: She's called globula and her sister's called like Santorini.

Ron: You're talking about going to the galaxy.

Ron: Her name is Nebula.

Laura: There we go.

Laura: Thank you.

Laura: Love you, bye.

Ron: So enzymes are Globular proteins.

Ron: That means that they're not fibres.

Ron: They're basically like little globules.

Ron: Okay?

Laura: Globules.

Laura: I like enzymes.

Laura: They sound down to earth.

Ron: Enzymes are cool.

Ron: This is like loads of what I study at university.

Ron: They have a feature on them called the active site.

Ron: This is like the epicentre of the trade fair.

Ron: Okay.

Ron: This is where the reaction takes place.

Laura: Right.

Ron: Write down also that we're learning about the lock and key method because that's about to come in.

Laura: I've done that, but just to annoy you, I've spelled it like a Scottish lock and then a key side.

Ron: All right, swampy.

Ron: So the shape of the active size, the locking key.

Laura: Welcome to the locking key.

Laura: We've got a seafood special for you tonight.

Laura: Would you like some garlic prawns?

Laura: Does it sound like a fancy hotel and a harbour?

Ron: What I didn't like was that you didn't get enough of a reaction over the way you spelled it.

Laura: Give me the reaction I'm looking for when I first seek it.

Laura: And then I don't have to misbehave, do I?

Ron: I'm sorry.

Ron: The shape of the active site is going to match whatever needs to react there.

Ron: They'll slot in like a key into a lock okay.

Laura: By that cool toy used to have.

Laura: You know that ball that had yellow handles and you pulled it apart and all the things fell out and then you put them in there in the colours.

Laura: It was red on one side and blue on the other side.

Ron: Sorry, absolutely no idea what you're talking about.

Ron: Right, so basically those will go into the active site of the enzyme, the reaction will happen and then they'll leave the active site.

Ron: The enzyme hasn't been used up because it's a catalyst and then it can carry on doing its job.

Laura: Okay, this thing, do you remember it?

Ron: Yes, I do.

Ron: Yes, I remember it.

Laura: I described that really well.

Ron: Good job.

Laura: What were you talking about while I was doing that?

Ron: How enzymes work.

Ron: Do you want to just fire that back at me?

Laura: They have an active site and it is the shape of the enzyme that's going to get jiggy on it?

Ron: No, the enzyme has the active site.

Laura: Then.

Laura: It's got an active site.

Laura: I think you stopped talking then.

Ron: Christ, this is like playing Chinese Whisper.

Ron: It's really horrible.

Laura: Well, basically you're going to say that that specific shape is the same shape as whatever's happening on it.

Ron: Of the things that need to react, yeah.

Ron: Locker key.

Laura: What is reacting?

Ron: Like we went through before.

Ron: There are different enzymes for different reactions.

Laura: Okay, what do you mean by reactions?

Laura: What reactions?

Ron: So there might be some enzymes that break down different molecules into smaller bits.

Ron: That's obviously what most of the digestive ones do, because their job is to take the big food that you eat, like you take a mouthful of basil or something, and then the enzymes in your stomach are going to break that down into small, tiny bits of basil.

Laura: I've got specific basil enzymes in there.

Ron: No, that was about so we can go through a couple of the different types now if you want.

Ron: You've got proteases for proteins, lipases for lipids or fats for carbohydrates.

Laura: You see, now we're just hanging out until I eat some of those.

Ron: Yes.

Ron: And then they start catalysing these reactions.

Laura: Okay.

Ron: Yeah.

Ron: So that's the lock and key method.

Ron: Okay.

Ron: I'm almost certainly going to put that in the quiz.

Ron: Knock all that into your head.

Laura: I've drawn a picture.

Ron: Did you bring the bread that I asked you to bring?

Laura: Was that a serious request?

Ron: Yeah.

Ron: Go get some bread.

Laura: I'm not going to get bread.

Laura: It's all the way downstairs.

Ron: Ask Tom for bread.

Laura: Tom.

Laura: I think we'll start getting annoyed if I keep bringing him.

Laura: Do I need some bread?

Ron: Yeah, go get some bread.

Laura: Am I allowed to eat it?

Ron: That's what you're going to do then?

Laura: Are we going to cut me open?

Ron: No, just go get some bread, please.

Laura: Okay.

Laura: Shall I pause the recording?

Ron: I'll see what I come up with and maybe edit it out.

Laura: Okay.

Laura: I'm going to get bread.

Ron: Hello.

Laura: Hi, Ron.

Ron: I got scared that I wouldn't be funny on my own, so I went for a wee.

Laura: No, that's hilarious.

Laura: I've got some bread.

Ron: Okay.

Ron: All right.

Ron: What you're going to do is take a bite of the bread and then just keep chewing it.

Ron: Don't swallow it.

Ron: Okay.

Laura: Don't swallow.

Ron: Don't swallow.

Laura: Just keep chewing.

Laura: The face of all the advice I've ever been given.

Ron: Disgusting.

Ron: I am your brother.

Ron: Woodlaus just fell.

Ron: Lost my room.

Ron: Be free, friend, before the cat eats you.

Ron: Oh, no.

Ron: I launched it into the radiator.

Laura: Oh, wrong.

Ron: Keep chewing.

Laura: I really want to swallow it.

Ron: Don't keep chewing.

Ron: How's that going?

Laura: Not really anything to chew.

Laura: A pulp.

Ron: Keep chewing.

Laura: I'm just mushing it with my tongue now.

Ron: That's fine.

Ron: That's fine.

Ron: Just keep chewing.

Ron: Holding it in your mouth.

Ron: You should notice after a little while that the bread starts to taste sweet.

Laura: Not really.

Laura: Well, I can't not swallow it now.

Laura: It's just going down on its own.

Ron: Keep chewing.

Ron: Is it getting sweet?

Laura: No.

Laura: This isn't science.

Ron: This is what I keep chewing.

Laura: Why don't you do this, too?

Ron: Because I'm the teacher.

Ron: I don't have any bread.

Laura: Well, I've swallowed most of it now.

Ron: Right, swallow then.

Laura: It's just going down.

Laura: It just tastes like glue.

Ron: Sweet glue.

Laura: No, let me try again.

Laura: Maybe I missed the sweet bit.

Ron: Eat loads of it.

Ron: Get more.

Ron: Buy off more.

Ron: Laura's struggling to chew this amount of bread now.

Laura: Dry.

Ron: You need more spit in your mouth.

Ron: Goggle.

Laura: Man.

Ron: My drawer is crunchy.

Ron: So I guess while I was doing this, I'll just explain what's going on.

Ron: So one of the hydrates, one of the enzymes that breaks down carbohydrates is one called amylase that exists in your saliva.

Ron: And what it does is it breaks down starch to make glucose.

Ron: So there's starch in bread.

Ron: So the longer Laura choose the bread, the more it's going to start breaking down the starch and it's going to make glucose.

Ron: The other word for glucose is sugar, common sugar.

Ron: So if you ever want just a sweet treat, go chew some bread.

Laura: No, that's not working because it's brown, red.

Ron: Maybe it has less starch in it because it's brown.

Laura: It's horrible rum.

Laura: It's like glue.

Laura: I'm sorry, I don't want to do this anymore.

Ron: Yeah, you can stop.

Laura: It got nastier tasting the more I chewed it.

Ron: Yeah, maybe it's because it's brown bread.

Laura: Can I go and get some white bread?

Ron: No.

Ron: Enough of this.

Ron: Yeah.

Ron: So that's kind of enzymes we did our first ever live experiment.

Ron: Didn't go well.

Ron: Did you hear my question?

Laura: I didn't choke.

Ron: Yeah, you didn't.

Ron: All right.

Ron: Did you understand clock what I was saying while you were doing that?

Laura: I've written down Amelie Spit.

Ron: Amelae's is in your spit amylaise.

Ron: So you can always tell an enzyme because it will have as at the end of it.

Ron: So you remember it was proteases lipasers carbide raises.

Laura: They're from New York.

Laura: They're the boys.

Laura: I'm an enzyme.

Ron: Yeah.

Ron: So that's in your spit, starch is a large molecule of glucose, essentially.

Ron: So what it does is it then starts chopping it up into little glucose molecules.

Ron: The other word for glucose, as you know, is sugar.

Laura: Fructose.

Ron: Fructose is a different type of sugar.

Laura: Glucose.

Ron: There's one called galactose glopula from the Galactose enterprise.

Ron: The last thing that we are going to learn is about bile.

Ron: Do you know what bile is?

Laura: Stomach acid.

Ron: No, the opposite, actually.

Ron: It neutralises the stomach acid.

Ron: It's very alkaline, so it neutralises the stomach acid.

Ron: So you don't literally just digest your own a**.

Ron: It also emulsifies fats that are in what you've eaten so that they're easier to break down because then they're dissolved and then the lipazers can get at them and cut them up into small little bits of fat.

Laura: Sometimes I'm listening to you, but I'm not hearing you.

Ron: What about that?

Laura: I can't even say it didn't make sense or didn't have logic.

Laura: I was just listening to every word you said and thinking about something completely different.

Ron: Well, how about this?

Ron: My suggested analogy to help you remember this, because bile is stored in the Gallbladder.

Ron: Remember we said we talked about the Gallbladder earlier?

Laura: You've got a call.

Ron: So I thought this maybe bile could.

Laura: Be asked Mr Bile.

Laura: That's what I'm getting confused with.

Laura: Because he's in Monsters, inc.

Ron: I thought bile could be don't walk away.

Laura: I'm here.

Laura: I'm just putting the spread out the window.

Ron: Why?

Laura: For the birds.

Laura: I don't want it.

Laura: It wasn't very nice.

Ron: Okay.

Laura: Sorry I'm back.

Laura: Suggested analogy time.

Ron: Yes.

Laura: I thought, let's get a new sting for Ron.

Laura: Suggested analogy.

Laura: That's the sting.

Ron: I thought file could be Asterisks and Obligations because they live in the Gallbladder.

Laura: Okay.

Ron: And the acid could be the Romans, because they neutralise the Romans.

Ron: And then I kind of lost it with the facts that they emulsify, but maybe that's like the secret potion or something.

Laura: Yeah.

Laura: I loved it.

Ron: Ron yeah.

Laura: Emulsify me.

Ron: So you know how oil and water don't mix?

Laura: Yeah.

Ron: Emulsification is basically the process of getting them to mix.

Ron: Do you remember the men that stand in a line?

Laura: They are my best favourite bit of this whole podcast.

Ron: Yeah.

Ron: So basically, emulsifiers are molecules exactly like that where they're hydrophilic, aka lovely.

Laura: Hydrophilic.

Laura: Why?

Laura: It's greased lightning.

Laura: I'm so glad I'm not editing this episode.

Ron: So they're hydrophilic at one.

Laura: You want to see my birth certificate?

Ron: All right.

Ron: We're not going to talk about emotions anymore.

Laura: Yeah, I am listening.

Laura: I just wanted to show you this.

Ron: It's good.

Ron: Just very good.

Laura: What are you saying?

Laura: Emotion?

Ron: It's not even in the syllabus.

Ron: You just asked and I was going to tell you, but we did.

Laura: I want to hear it, please.

Ron: So, you remember our little men that stand in a line in the membrane?

Laura: Yeah.

Laura: Michael Flatly.

Ron: Yeah.

Ron: So their head is charged and it likes water, right?

Laura: Yes.

Ron: And then their tails don't like water.

Ron: Hydrophobic and hydrophilic.

Laura: Hydrophilic, yeah.

Ron: So that's what emulsifiers are like.

Ron: Because then the tails can go into the fat and then the heads can go into the water and then they can all mix up, essentially.

Laura: Perfect sense.

Ron: It does, doesn't it?

Ron: And that's it for today.

Ron: How are we doing for time?

Laura: I don't know, because we spent a lot tough time going to get bread and doing other things.

Laura: Yeah.

Laura: It's probably an episode, isn't it?

Laura: Well, I've made a lot of notes.

Ron: Ron good.

Ron: I think all of that makes sense, though, right?

Ron: None of it is just, like, made up.

Laura: It's almost made up, isn't it?

Laura: When I'm making notes, they make so much sense.

Laura: Then when I look back at them, I've written down today, I've written biology at the top of the page.

Laura: And then I've written you salt to kill slugs.

Ron: So you actually just made zero notes on how that works or why that happens.

Laura: Water chases salt, and then an enzyme is a Catalina.

Laura: An enzyme equals one type of business, globular in capital letters Globules.

Laura: Next to it, small letters, lock and key.

Laura: And I've drawn a picture of a pair next to that.

Laura: Amelie Spit.

Laura: Enzymes are from New York.

Ron: Well, see how you do on the quiz in just a few moments.

Laura: Hello, Ron.

Ron: Hello.

Laura: Oh, my God.

Laura: I really look forward to doing these recordings.

Laura: And then we sit down to do the quiz, and I can't even remember what we did last time.

Ron: Sometimes I feel like that too, and I'm excited for a core day, and then I start doing the research for it, and I just get this impending sense of dread.

Laura: Yeah, right.

Laura: Hang on.

Laura: Where's my notepad?

Laura: I tucked some stuff in it.

Laura: What were we doing?

Laura: What notes have I got from last time?

Laura: globula.

Laura: Amelie is spitting enzymes are from New York.

Laura: Catalina Wine mixer.

Laura: Well, let's start the quiz before we.

Ron: Jump into the quiz.

Ron: Laura, last time you were set some homework was I?

Ron: Yeah, to go make Tom and your friend Leanne or whatever.

Ron: Jacqueline.

Ron: Jacqueline.

Ron: Yeah?

Ron: Choose some bread.

Laura: Did they do that to do it wrong?

Ron: For f***'s sake.

Laura: The dog ate my homework and she didn't either.

Ron: That would have been closer to what you should have done.

Laura: Shoot.

Laura: Sorry.

Laura: Yeah, I'm bad at that.

Laura: I forgot it.

Ron: Well, that's fine.

Ron: Well, maybe I'll set some more homework after this.

Laura: I don't because I'm bad at it.

Ron: Right.

Ron: Are you ready for the quiz?

Laura: Yeah, buddy.

Laura: Quiz me.

Ron: Today's quiz for those following along at home is out of 123-4567 eight points hot Cuisine.

Ron: Okay, number one for two.

Ron: There's two things you need to say as part of this answer.

Ron: We're going to start doing this a little bit more official like, okay?

Laura: No, don't get strict with me.

Laura: I'm not in a position to be.

Ron: Stricted on well, it's just because I'm bored of being sort of talked into giving you marks.

Ron: It's like, oh, well, if you kind of think about it, it is what I said.

Ron: Really, or it's at least what I meant while I was saying something else.

Ron: Then I figured you crying.

Laura: No, I was burping.

Ron: Okay, so two marks, two things you need to say as part of your answer.

Ron: Question one what is osmosis?

Laura: And then they're going to be specific words you want me to use.

Ron: Yes.

Ron: There's at least four things you need to mention.

Laura: Four.

Ron: I've managed to sum it up in a.

Laura: I haven't even written down osmosis.

Ron: In a twelve word sentence.

Ron: I've gotten both marks.

Laura: I haven't even written down the word osmosis in my notes.

Laura: I've got to start making better notes.

Ron: Yeah, we talked about osmosis for the majority of the last episode, I think.

Laura: God, what happens to my brain in these weeks?

Laura: Osmosis.

Laura: Right.

Laura: Let me say it my way and then this isn't my answer.

Laura: I'm working out my answer.

Laura: And then I'll try and convert it into Ronspeak.

Laura: It's like slurping it across the membrane, isn't it?

Laura: It's like.

Ron: Slurping what?

Laura: Water absorbing water across a membrane.

Ron: That's one mark.

Laura: That's one.

Ron: The movement of water across a membrane.

Ron: Ding.

Ron: One mark.

Laura: And there's only one more mark, isn't there?

Ron: There's only one more mark.

Ron: Yeah.

Laura: Salt.

Ron: It's in the right ballpark.

Laura: Concentration.

Laura: Gradient of salt will make water do osmosis.

Laura: He's doing a half nod, but he looks pained.

Laura: I need to say more slugs.

Ron: No.

Ron: Formulate a sentence before you start speaking, because you came up with salt and then concentration and then tried to build the sentence from there.

Ron: Use those things, but just plan for it.

Laura: Hello, my name is The Salt, and you've got less salt than me.

Ron: I said plan, essentially, not your role play.

Ron: That wasn't part of it.

Laura: If you have more salt in your blood, why are you doing it now.

Ron: In the style of an advert?

Laura: Because you said to plan a sentence and I'm trying to.

Laura: I don't like planning sentences.

Laura: I like just talking and seeing what happens.

Laura: Hey, guys.

Laura: If you've got too much salt.

Ron: It'S not a Tweet.

Ron: We don't need a tweet.

Laura: I don't know how to do this.

Laura: If there's too much salt in a thing, the water will come and get in it too.

Laura: To calm down.

Laura: I dunno how to do this. Just if there's too much salt in a thing, the water will come get in it to, to calm down the salt.

Ron: I'm gonna give you half a mark for the second bit. Okay. Cause I think, you know what you mean? 

Laura: I'm saying what I mean!

Ron: So here's what you, here's 

Laura: what you mean. If you are just about, I know you were just about to say exactly what I just said. Okay. 

Ron: Movement of water across a membrane from low concentration to high concentration

Laura: I said that!

Ron: No you didn’t

Laura: I did, did said concentration gradient.

Ron: Yes, but you didn't say from low to high, you just said what you said was salt concentration gradient. Hey guys. 

Laura: cause you are flustering me. 

Ron: Okay. I think that's generous one and a half, but so there you go. Okay. Question number two again, for two points. Why would an organism invest energy in active transport?

Laura: Is the lock and key method. 

Ron: no, shit. Um, don't look at your notes. There's now there. 

Laura: what was I writing down then? I'm gonna make such good notes in today's episode for next week. Um, would it be because they. Are transporting something that can't be diffused or, or mortified or morphed, what was it? O morphed as morphing morphed.

Laura: Have you got your window open? Mm-hmm it's nice. get. like, if you needed to move ATP around, maybe that can't go by OSM, morphing. What is this word? I've got it out of my head again. Osmosis, osmosis. I need to write that 

Ron: down my pen. So you've named the two passive processes there. Yeah. Diffusion as an osmosis.

Ron: Yeah. The, those are both dictated by concentration 

Laura: gradients. 

Ron: Yeah. So active transport. This last. Yeah, we did. We've done it for like the last two biologies. Really? Um, so active transport 

Laura: would all is when you haven't got a concentration gradient or 

Ron: a membrane? No,

Laura: a solution. No, 

Ron: gravity. It's when there isn't a concentration gradient or you need to move something bigger. Try the wrong way up or down the concentration gradient. Ah, 

Laura: okay. 

Ron: Also to move things quickly, 

Laura: you might need to close your that's very noisy. Okay. 

Ron: Also to move things quickly. So, okay. Neil question two.

Laura: I don't remember doing that. I don't think we talked about that. 

Ron: We certainly did. Um, question three for one point. What is a catalyst? Oh, I've just realized you don't get points in a quiz. Do you get marks in like a school? I 

Laura: like giving points feels more showbiz. Um, okay. A catalyst is a place where a thing can happen.

Laura: It's like a it's. it's a site that allows, uh, a reaction to take place and speeds it up. 

Ron: It's one there's there's one thing you need to say,

Ron: it's an enzyme. No enzymes are catalysts. 

Laura: Uh, it's neutral. 

Ron: I can't give this. No, 

Laura: you can't come on. I did say it. A catalyst is like a, it's like a place where a thing happens. It's 

Ron: not even necessarily a place. So it's being quite nice by letting that slide a catalyst is something that speeds up a reaction without being used up itself.

Laura: oh, okay. Catalyst doesn't get used up. Yeah. 

Ron: That's the really crucial bit because there are other things that can speed up a reaction, but if they get used up themselves, they're like an accelerant or something. Okay. Whereas a catalyst is in its original form at the end of the reaction. And then your thing with it being a place that is kind of true of enzymes, but not necessarily all catalysts.

Ron: Oh. Because you can just add stuff to, in a reaction, it could be a catalyst without it, you know, and it could also be in solution or something like. Okay. Okay. The next one for one mark out of this multiple choice, you're going to tell me which of the following is an enzyme. 

Laura: Please be alas, 

Ron: a amino pep B Lippes C YL gin.

Ron: D extract in B. 

Laura: I'm gonna say the one lipase, because I've written down A's enzymes are from New York. So I think things end in an a are enzymes. 

Ron: Yes, it is lipase. Well, 

Laura: fast, useful note, first useful note. 

Ron: Did it help that I loved was saying vigisamine? 

Laura: What is vigisamine? 

Ron: Vigisamine? It's nothing. I made that up.

Ron: That's why I think is so funny. um, yeah, all of the other ones are fake things that are made up to sound sciencey. Um, and then the question number five. What does lipase do? 

Laura: Uh, dissolves 

Ron: fat. It does digest fat. Yes. Well done. How did you 

Laura: remember that? Lipper suction. 

Ron: Yes, because a lipid is another word for a fat.

Laura: Yes. And they, you were explaining to me fats and oils don't mix together. And that's a membrane is like lipids and water. The bio lipids are on membrane side. Yeah. But lipo, suction, lipo action. C that made me, do you know what film that's. Paula suck in the cheeks. No, it's Richie rich. Oh, you know when she's doing the mountain, 

Ron: it's been maybe 18 years since I've seen Richie 

Laura: rich, you brought it up the other day though.

Laura: You said it was like the goo in Richie rich. Oh, it's on the Netflix, I think. Well, maybe not in Brussels though. Stupid Brussels. 

Ron: Where too heavy into Buffy the vampires layer at the moment. 

Laura: Yeah. We just finished it Creek me for the, anyway, this is nowhere to end an episode. Um, alright. How many did I get then?

Laura: Like two, 

Ron: one and a half plus one plus one. Three 

Laura: and a half, three and a half out of eight. Oh, all right,

Laura: Ron. I can't believe how little you came up with when I went to get bread. yeah, nothing. I thought that'd be at least like a minute before you beat it out, but 

Ron: no, no, no. I'm not a confident. 

Laura: Also, how are you so young that you dunno what to Vega buses, if anybody's listening and is equally as outraged as me, that Ron.

Laura: So I do another podcast, the national treasures podcast, and, um, on our patron podcast, we do years and years. And we look at births and deaths from years in history. And will my co-host on that? Finds it weird when, like, I can't remember like the last emperor of Japan or something was died. The same year Taylor swift was born.

Laura: I find it creepy that you are a grown adult that I'm talking to and who knows about things, but you don't know what the Vega bus is. Yeah. But when 

Ron: I was at school discos getting fucked up on Panda pop, I 

Laura: thought you were gonna say fingered for a second. And then I was taking a sip tea as you did it. And honestly, All of that upper arm, kissing bile came straight back up the back of my throat.

Ron: Yeah. When I was at school discos, getting pegged out by the bins. um, you know, things like 

Laura: that, no picturing a bin pegging you 

Ron: don't um, things like the van bus would come on and we'd listen to it. It was like, that was basically oldies to us. Oh my God. That's 

Laura: like your bony M. 

Ron: It's like my Bon. Yeah. And you know, it'd come on.

Ron: He'd be like, oh yeah, bangers. Um, it's like the Beatles or something. 

Laura: Ugh. Um, Yeah, you're too young. You're just too young. Get older, please. Um, I've thought of a correction to my Priti Pasell political topical comedy. It can now be seller Braverman, Sue seller, Braverman, Sue seller. Braverman. Yeah. All. Hmm.

Laura: We'll think about it. Let us know what you prefer. Sue brave. Maybe that is better. Dammit, Ron, I 

Ron: that's. I saw your notes and I didn't change it. Cause I wanted to upstage you on the podcast.

Laura: Why did you take my one thing? 

Ron: your one thing is not Sue brave, her name pun. You're not even really a political satirist. 

Laura: No, because it just makes people angry and I didn't really get into comedy to be shouted at all the time. Yeah. 

Ron: The Internet's a very strange place 

Laura: at the moment. Yeah. Um, any who, so, um, on the merch front, cuz we have been discussing this just, you know, we, we don't even know if we'll do merch, but we'd like to be in a position to be able to do merch as the little podcast grows and grows.

Laura: Um, leading suggestions so far are tide protection, helmet, baseball, caps, and notepads, but maybe with, you know, the, the left hand side of the page that nobody likes writing. No. Yeah. Right. Here's a notepad. Yeah. Yeah. You know how, when you're writing you, don't, you hate the bit where you've got right on that side of the page when it's open, flat, that's the right hand side.

Laura: It isn't, that's left if you're writing in it that, oh, 

Ron: that 

Laura: whole page. Yeah. It's horrible to write on, cuz it's not as flat and squashy as the other side. 

Ron: I don't, I don't really write in notebooks to be honest. I don't think I've written with a pen in the last four. 

Laura: Ron. That's so sad for all your pens. Um, well, I was thinking on that side of the note we could put my notes from my note.

Laura: I wasn't thinking that somebody suggested that, but I was thinking it could go there. That's God, I'm tired. Okay. So those are the . Those are the merch suggestions so far. Let us know if you have any further suggestions. Um, I think that's it from us this week. 

Ron: I think that's it. Yeah. It was a lovely episode.

Ron: We loved doing it. We're back. 

Laura: Would you what? You're stop talking. We didn't go anywhere. Yeah. You went 

Ron: on holiday for two 

Laura: weeks. Oh, okay. We're back. We're back. I thought you were gonna carry that arms, like we're back next week with blah, blah, blah. No, we're just, just back we're back. Yeah. So have a lovely kiss on the upper arm from 

Ron: us.

Ron: You're gonna kiss on the back of the knee from me. 

Laura: I would see next week when we're back to chemistry. Bye. 

Ron: Class dismissed.