Ate Out of Ten Cats

 Ron: Hello and welcome to a new podcast called The Ron Cast, the first episode of what is clearly going to be tour de force of the podcasting world.

Ron: Get ready for one straight white man's opinions on a variety of things, including, but by no means limited to the GCSE triple science syllabus.

Ron: My name's Ron and this is the Roncast.

Ron: No, I'm just joking.

Ron: Listeners, welcome to Lex Education, the comedy science podcast, where me, a normal man called Ron, teaches science to his sister, who is also a comedian, Laura Legs.

Ron: Laura's not here today.

Ron: She couldn't be bothered to turn up for the intros and outros.

Ron: It's just her birthday and she was like, oh, I just want to not work before I go to work later on.

Ron: Doesn't matter that you're really ill, Ron.

Ron: You have to record the intros and outros.

Ron: guachar.

Ron: She cracks the whip and I have to do it.

Ron: But that's fine, I don't mind.

Ron: She's had to do on her own as well before everything's okay.

Ron: So what are you in for today?

Ron: Episode 68, one before the funny one.

Ron: Good episode.

Ron: I was saying last week that was a bad episode.

Ron: Now my chickens are coming home to roost, because I can say without doubt and with you guys knowing that I'm not being overblown or hyperbolic, this is a really good episode.

Ron: Lovely little episode, biology.

Ron: We get on for the whole thing.

Ron: I'd say Laura's got a bit over the top with the sound effects on this one.

Ron: Didn't love, you know, it is what it is.

Ron: She edited this one, I'll edit the next one and I'm not going to put in any sound effects in that one.

Ron: It evens out.

Ron: There's a new Patreon episode coming out soon.

Ron: We're like a couple of patrons off doubling the content on there.

Ron: So the bang for your buck is about to double.

Ron: If you're thinking about signing up for there, it's only three quid a month and you get loads more of this.

Ron: Well, not this, because there's both of us.

Ron: Nobody wants this.

Ron: And then just big shout out to the big X herself.

Ron: She's completed Cook Serve Delicious Three on her birthday of all days as well.

Ron: So well done, her.

Ron: Let's get on with the show.

Ron: Lovely podcast stuff that we do.

Laura: Oh, the joy of having just done a physics quiz means it's biology now.

Laura: Although even the biology has not been that great, has it?

Laura: All of science is just becoming a mucky puddle.

Ron: That's sad for you that you think that.

Laura: Yeah.

Laura: What are we doing today?

Ron: Biology.

Laura: Yeah, what are we doing in biology?

Ron: Wow.

Ron: Okay, you're going to need to leave that tone at the door.

Laura: I've got cold, I don't feel well.

Ron: Yeah, but you're a profession, so suck it up.

Laura: No, I don't have to be a professional here.

Ron: Why not?

Laura: Not very many people are paying for it.

Ron: Loads of people are paying for it.

Laura: Not this episode.

Ron: No, nobody's paying for this.

Laura: Give us a like be nice.

Laura: I will be in 45 minutes.

Laura: When we switch from this to the patreon episode we need to record, I will switch into peppy, peppy, peppy mode.

Laura: But for these freeloading f****, I'm giving them nothing.

Ron: All right, I'll give them nothing as well.

Laura: No, you love biology.

Ron: So we're doing at the moment, we're moving on to a new section 5.9.8.

Laura: Much simpler, I should guess that when it's a new section.

Laura: It's a simple number.

Ron: You can remember this one because it's your height and feet.

Laura: I'd love that.

Laura: Half a foot, mate.

Laura: Turn the jerk back on myself.

Ron: That's not really turning it, that's just pushing.

Laura: This would be a hilarious bit, Ron, if you were six foot five and the world's most gorgeous man.

Laura: But you're a little Hobit too, so I'm not.

Ron: I am perfectly average height and I am a gorgeous man.

Laura: Someone's been doing their bedtime affirmations.

Ron: We're doing 4.5 homeostasis and Response.

Laura: Doesn't sound good, Ron.

Laura: What's good to uh I don't know, how does baking work or something?

Laura: Well, I made some bread today.

Ron: That's not really something that you do in science.

Laura: Home sciences.

Ron: That's not the podcast.

Laura: No, I understand.

Laura: Homeostasis, yes.

Ron: What are you doing here?

Laura: You type I'm typing it into the spreadsheet that you never use.

Ron: Why are you doing that now?

Laura: Because that's where I write down what each episode was about, so I remember.

Laura: I know you don't think writing anything down is useful, but I do.

Ron: Yes.

Laura: I miss the days where we used.

Ron: To like each you're okay?

Laura: I feel very despondent today.

Ron: Yeah, I know, it's quite horrible.

Ron: So we're doing homeostasis and response.

Ron: Laura, do you know what homeostasis is?

Laura: Stasis tends to mean staying still.

Laura: Or if something's in stasis, it's like frozen or paused, isn't it?

Laura: Homeo, homeo, wherefore art thou homeo?

Laura: That's a lot of business.

Laura: Thank you.

Laura: Tends to meet actually.

Laura: I don't know what that means.

Laura: Homoeopathic remedies homeo.

Laura: It's not quite h***, which means like singular, doesn't it?

Ron: Or the same.

Laura: Yeah, the same.

Laura: Homeo.

Laura: No, I don't know, something staying paused.

Ron: You could be further away.

Laura: Thanks, Ron.

Laura: That's the kindest thing you've ever said to me.

Laura: And I tried.

Laura: Didn't I try?

Ron: Yeah, that was good.

Ron: You see how I didn't say don't just say things?

Ron: Because you weren't just saying things, you were applying logic.

Laura: I'm kind sometimes.

Ron: Yeah.

Ron: Sometimes you are.

Ron: Right.

Ron: So homeostasis, Laura, is essentially the regulation of your body.

Ron: So homeostasis is the internal conditions homeostasis is the regulation of the internal conditions of a cell or organism to maintain optimum conditions for function in response to internal and external changes.

Ron: Okay, so let's break that down.

Laura: Can you read that again?

Ron: Yeah, like I said, let's break that down.

Laura: Can you just read the whole thing again quickly, because I forgot.

Ron: Homeostasis is the regulation of internal conditions of a cell or organism okay, to maintain optimum conditions for function in response to internal and external changes.

Laura: Oh, okay.

Laura: So it's like a little rule book.

Laura: Like a little government?

Ron: No, you could be closer on that one.

Ron: It's it's more like the weather inside you, but if you had control over.

Laura: It so it's like choosing what to wear when weather happens.

Ron: It's kind of like do you need to open the windows to make it a bit colder in your house and let some fresh air in?

Laura: Yeah.

Laura: Like a little government.

Ron: I guess.

Laura: They're like the housing market's crashing.

Laura: We're going to stimulate the economy.

Laura: Bloop bloop bloop massage the banks.

Ron: Okay, yeah.

Ron: Metaphor doesn't really work for me.

Ron: But this is your show.

Ron: Let's go for it.

Ron: Do you think?

Laura: My show?

Laura: It never feels like a show.

Ron: Yeah, your name's in the title, not mine.

Laura: That's because probably if we'd called it Ron's Podcast, it would do 20 times better.

Laura: The roncast nice.

Laura: What's Ron?

Laura: His mind.

Ron: Yeah.

Ron: Rip that segment.

Laura: Is it dead?

Laura: Are you never bringing it back?

Ron: Can't have a segment that comes in and out.

Ron: It's gone.

Ron: It's gone.

Laura: Oh, Ron.

Ron: Well, nobody was enjoying that segment.

Laura: I loved it.

Ron: I guess I wasn't.

Laura: We have a go at my concentration span, but mine's bad on a microcosm.

Laura: Yours is bad on the macro.

Ron: Yeah.

Ron: I think it's because I leave everything to the last minute.

Laura: Why do you do that, Ron?

Ron: I'm busy.

Laura: Doing what?

Laura: Catching up on all the other things you've left to the last minute.

Ron: Working.

Laura: You socialise a lot?

Ron: Socialise a lot.

Ron: I'm in a band.

Ron: I have a podcast.

Laura: You get buff at the gym.

Ron: Yeah, I go to the gym four, five times a week.

Ron: I'm a poet, I'm an artist.

Laura: I made a delicious dinner last night.

Ron: A live dancer.

Ron: What?

Laura: I fed Agony dad a Lentil cottage pie and he liked it so much he had seconds.

Ron: Very nice.

Laura: Pretty cool.

Laura: Laura yeah.

Ron: When we were on the boat, we had just pesto pasta one night and he was like, what meat's going in this?

Ron: And I was like, none.

Ron: Loads of mushrooms.

Ron: And he was like, all right.

Laura: I figure we waved Agony dad off on his gap year last night, so I figure he's only going to eat meat for the next six weeks, probably, and chips and things that you find in the various ports of the Mediterranean.

Laura: I can't see him eating a green vegetable between texted me out of the blue.

Laura: Yeah.

Ron: Just to say something chatty.

Ron: It was nice.

Laura: What did he say?

Ron: He said, Is it methos o'clock yet?

Laura: I think he, contrary to what he'd like us to believe, does get lonely when he's away from us.

Ron: Yeah, he's a good lad.

Laura: I do think he was quite ashamed of the fact that we all play minecraft together all the time last night.

Ron: Yeah, but Mum sits around and plays Marjong all the time and he plays stupid games too.

Laura: Yeah.

Laura: He was playing Candy Crush as he was criticising us for playing Minecraft.

Laura: So I just don't really get it.

Laura: I don't get what the point is.

Laura: And it was like you're literally playing Candy Crush.

Laura: Where's that going?

Laura: We've built an empire.

Ron: Exactly.

Ron: We've got projects for days.

Laura: Yeah.

Ron: Let's not do the patreon content we were planning.

Ron: Let's just play minecraft.

Laura: No, we need to record I'm up for playing Minecraft tonight.

Laura: But we need to record an episode.

Ron: Yeah.

Ron: No.

Ron: Yeah, but no.

Ron: For patreon content.

Laura: Someone did tell us that they'd tell us how to twitch, didn't they?

Laura: Let's Google how I'll put that on the spreadsheet because I had an idea that we could do an episode where we do a puzzle together.

Ron: That would be nice.

Laura: Would you enjoy that?

Laura: I was thinking of calling them Wet Breaks.

Ron: I think that name is gross.

Laura: Is that not what you called it when it was raining at Playtime?

Ron: I think worse.

Ron: We called it wet play.

Laura: But wet break is nicer.

Ron: Yeah.

Ron: There's no single way to stream on twitch.

Laura: I think let's not research this now.

Laura: And someone did message us and tell us they'd help us to do it.

Laura: Ron.

Ron: Okay.

Ron: Get back in touch, please.

Laura: No, I'll just find the message.

Laura: Don't feel you need to.

Laura: We will do some work for once.

Laura: I'll find it.

Laura: Maybe we could add that to the December roster for patreon content.

Ron: Yeah.

Laura: Anyway, we should probably do the non patreon content now.

Ron: Okay.

Ron: Right.

Laura: I'm so glad I'm editing this episode because you would have left all of that big chat we just had in whereas I'm going to edit it down to a little funny aside.

Ron: Lame.

Ron: Right.

Ron: Homeostasis lore.

Ron: Regulation of internal conditions.

Ron: What conditions do you think that could apply to?

Laura: Hydration?

Ron: Yep.

Laura: Temperature?

Ron: Yep.

Laura: Oxygen supply?

Ron: Yep.

Laura: Tiredness energy?

Laura: Glucose.

Ron: Blood sugar levels?

Ron: Yeah.

Laura: ATP production?

Ron: Kind of.

Laura: Yeah.

Laura: Hormone regulation.

Ron: Now, that was going to be my next question.

Ron: Laura, how do you think we monitor how do you think we affect all of this stuff?

Laura: Hormones.

Ron: Because what are hormones?

Laura: Chemical signals.

Ron: Well done, Laura.

Ron: You're very smart today.

Laura: Yes.

Laura: And every day ron.

Laura: You just don't always access it.

Ron: Potato.

Ron: Potato dapado.

Ron: That is how child of the podcast is tomato.

Laura: No, that's Tapato.

Laura: Dabado is potato.

Laura: Very subtly different.

Laura: Belbow.

Laura: Belbow was the first word she said when she woke up this morning.

Ron: Very nice.

Ron: That's elbow.

Laura: Yeah.

Ron: She's a big fan of Grounds for Divorce.

Laura: Is that a musical album by the band Belbow?

Ron: It's a song by the band Belbow.

Laura: I love it.

Laura: She's actually a big Simon fan.

Ron: Yeah, she's got good taste.

Ron: Takes after her uncle.

Laura: Anyway, you were saying how smart I am today.

Ron: Yes.

Ron: Glazed over for a second.

Laura: You did?

Laura: Yes.

Ron: What were we talking about before then?

Laura: Hormones being electrical charge messengers.

Ron: Yeah.

Ron: Nothing to do with electrical charge.

Ron: Scrub that out of your brain.

Laura: No, I got it right the first time.

Laura: Just use that one again.

Laura: Use that as a cut and paste.

Ron: No, you do that in your brain.

Laura: What did I say?

Laura: Chemical messenger.

Laura: Chemical messenger?

Laura: Yeah.

Ron: Because it's not electricity, is it?

Ron: It's a chemical.

Laura: No, but would it be an electrical impulse in your brain that makes you release the hormone?

Ron: Yes.

Laura: Cool.

Ron: Well, if sometimes so that's what we're going to be looking at.

Ron: That's this section.

Laura: Okay, just to I like the sound of this.

Ron: Clearly explain this to you.

Ron: That was scene setting.

Ron: Okay.

Ron: And now we're going to move into content.

Laura: So do I need to write that down?

Ron: What do you mean?

Ron: For what?

Laura: The scene setting stuff.

Ron: But it's kind of up to you.

Laura: Okay.

Ron: To what end?

Ron: What do you want to get out of this?

Ron: What are your goals?

Ron: How will you know if you've done?

Laura: Well, I'll be on eight out of Ten cats, I suppose.

Ron: Okay.

Ron: Do you think that's achievable and what?

Laura: No, I'm a woman.

Ron: What steps do you need to take to get from where you are now to get there?

Ron: Let's break it down into achievable.

Ron: Little bite sized bins.

Laura: I'd need to go back to the beginning of my career and focus on one single aspect of comedy and become the representative of that rather than just trying to be more generalised.

Ron: We can't do that.

Ron: So let's go from now, what can we do?

Laura: Focus all of these lessons on time travel so I can go back to being 22.

Ron: Time travel is not is kind of outside of our capabilities.

Laura: Then rename this podcast, Eight out of Ten Cats so that I can achieve it off my own back.

Ron: Okay.

Ron: This episode is going to be called.

Laura: Eight out of Ten Cats.

Ron: Say out of ten cats.

Ron: Even still going.

Laura: I don't even know, Ron.

Laura: I don't know.

Ron: Well, life goal achieved.

Ron: You've been on Eight Out of Ten Cats, because we're going to call this episode eight out of Ten Cats.

Ron: I've been on a coaching course recently, Laura, so that's why I've just helped you fulfil your goals.

Laura: Thank you.

Ron: Yeah.

Ron: Feels good, doesn't it?

Laura: Hey, for Halloween, you could say I've helped you achieve your goals.

Laura: Mystery that they won't have me on this show.

Ron: Really?

Ron: Jarring non secretaries, like, just says something weird about makes a seasonal joke for a season that it's not, and then hacks up a lung and then just looks at David Mitchell expectantly.

Laura: I'd be a hit.

Laura: Nobody's doing comedy like that anymore.

Ron: Yeah, okay.

Ron: Right.

Ron: The optimal conditions that homeostasis dictates your.

Laura: Eyes just went all the way back up in the top of your head then.

Ron: No, I rolled them.

Laura: Don't do that.

Laura: It's horrible.

Laura: You look like a ghoul.

Ron: What do you think those optimal conditions are for mainly.

Laura: Healthy living rain episodes.

Laura: Can you hear the rain?

Ron: Yeah, healthy living.

Ron: That's kind of the definition of homeostasis.

Ron: But what are these conditions for?

Ron: Is it the conditions that melts metal?

Ron: Would that be helpful for us?

Laura: I've got to be totally honest, Ron, I didn't hear the first bit of what we were talking about when so I've been trying to backpedal and guess and I don't know what we're talking about.

Ron: You don't know what homeostasis is?

Laura: I heard that bit, but what were you saying when you were rolling your eyes?

Laura: Because I got so distracted by you being possessed by a demon.

Laura: I missed that bit.

Ron: Homeostasis is the conditions in your body, right?

Laura: Yeah.

Ron: What do you think those conditions are aimed at?

Ron: What's the target audience for those conditions?

Ron: Basically.

Laura: In which case I heard everything.

Laura: I just don't understand what we're talking about.

Laura: What are you talking about, Ron?

Ron: What are the sort of the drivers of biological functions in your body staying alive.

Laura: And reproducing?

Ron: What does that mean?

Ron: What are the drivers?

Ron: What gets s*** done in your body?

Ron: What does stuff hands in your body?

Laura: Muscles.

Ron: What gets muscles to move?

Ron: What builds muscles?

Ron: What breaks stuff down?

Ron: What does biological process?

Laura: Enzymes.

Ron: Yes, absolutely.

Ron: And what else does stuff inside your cells?

Ron: What's inside your cells?

Laura: Organelles.

Ron: There we go.

Ron: Those have functions, don't they?

Laura: Yes.

Ron: They do.

Ron: Sometimes I don't.

Laura: So enzymes and organelles, if you were making notes, what would you class them as then?

Laura: Driving forces of your body, what do they do?

Laura: Stuff, loads of stuff.

Laura: They do the processes.

Laura: Processes?

Laura: Processes, processes.

Laura: Ron, listen to that rain.

Laura: I think that's your rain I can hear.

Laura: Is it processors?

Laura: Ron, Ron, come on.

Laura: I'm trying.

Ron: What do you mean by processors, mate?

Laura: Is that what they're doing?

Laura: Is that who they are?

Ron: What does that mean?

Laura: I don't know.

Ron: What's an enzyme are they?

Laura: The drivers?

Laura: Drivers?

Ron: What's an enzyme?

Laura: An amino acid.

Laura: Amino acid is like that puzzle piece that you keep picking up and trying in lots of different spaces and one day it'll fit somewhere, but I don't know where.

Ron: Told you so many times what amino acids are.

Laura: I thought enzymes were little chemicals.

Laura: They are, yeah.

Laura: All right, there we go.

Ron: What do they do?

Ron: If there had to be a tagline for enzymes, what would it be?

Laura: See, that's what would come in real handy with this.

Ron: Biological catalysts.

Laura: Biological catalysts?

Ron: Yeah.

Ron: We've said that before, haven't we?

Ron: No, we have.

Ron: Yes, we have.

Laura: Biological catalysts, okay.

Laura: And organelles are very varied.

Ron: So enzymes, okay.

Ron: Your eyes look so sad.

Laura: So if we were classing those two as something in this context, would we call them?

Laura: What would we call them, Ron?

Ron: We'll just call them what they are and remember what they are.

Laura: You're so obtuse when I'm trying.

Ron: I'm not being obtuse, but they're different.

Laura: You asked me, you said if we had to come up with the driving factors of something or other, and then the answer was enzymes and organelles.

Laura: So now I'm asking you to reverse engineer that and just tell me what it was you said they were that we were looking for when you needed me to say enzymes and organelles.

Ron: Yeah, but I'm trying to lead you there.

Laura: I'm not going to get there.

Laura: My legs are broken.

Ron: No, let's try and get you there.

Laura: Because no, just say it so I can write it down and we can move on.

Ron: No, because with so much this stuff, especially when we're talking about things like metabolism, which means all of the reactions that are going on in a cell, we simply cannot start from zero every single episode.

Laura: All right, Kirstarmer, but sometimes we need.

Ron: To we can start from zero now.

Laura: But tell me this one sentence and we'll move on.

Ron: Because I've been no, because you're going.

Laura: To say, that such a weird place to dig in, Ron.

Ron: No, because you have to understand what's going on in understand?

Laura: I just need you to tell me.

Ron: Laura, you just asked if enzymes were amino acids.

Ron: You do not understand.

Ron: Laura?

Laura: Yeah?

Ron: Why are you being in emotions?

Laura: I was playing with my printer ink cartridge and now I've spilled printer ink everywhere.

Ron: Wow.

Ron: If only we could have seen that coming.

Laura: Know that they could leak.

Laura: If you had ink in you, why did you bleed on at me?

Laura: To change.

Laura: You didn't even know they could leak.

Laura: Ron.

Ron: I don't think I've ever seen a printer ink cartridge.

Laura: Oh, here you go.

Ron: Yeah.

Ron: No, never seen that before.

Laura: I suppose you're a different generation to me.

Laura: You've never owned a printer?

Ron: No.

Ron: I can't remember the last time I printed something out.

Laura: The planet thanks you.

Ron: Yeah.

Ron: I'm wasteful in other ways.

Laura: Waste hours of my week doing this.

Ron: Right.

Ron: Laura?

Laura: Yeah.

Ron: Can you focus up again?

Laura: Yeah.

Laura: You've dispirited me somewhat.

Ron: Name some organelles.

Laura: Ribosome.

Ron: What do they do?

Laura: Make ATP?

Ron: Nope.

Laura: Really?

Laura: I thought they laid eggs.

Ron: What comes out?

Laura: They make proteins.

Ron: Yeah.

Ron: What makes ATP the powerhouse of the cell?

Laura: Does it begin with.

Ron: And then.

Laura: Mitochondria?

Ron: It is mitochondria, yeah.

Ron: Can you name the other organelles?

Laura: Cytoplasm.

Ron: That's more just kind of the milieu.

Laura: Nucleus.

Ron: Yes.

Ron: What does that do?

Laura: Holds the DNA.

Ron: Yes.

Ron: Very nice.

Laura: Can you name any cell?

Laura: Wall?

Ron: Yes, that's one implants.

Ron: Can you name any others?

Laura: Flagellum.

Ron: Yes.

Ron: What does that do?

Laura: Moves things around.

Ron: What things?

Laura: Oxygen.

Ron: How would that work?

Ron: That's an example of just saying things.

Laura: Membrane.

Laura: Cell membrane.

Ron: No, it's still on flagellum.

Ron: What does it do?

Laura: It moves things around.

Ron: Moves what around?

Laura: Protein.

Laura: ATP.

Ron: A Flagellum just pushes around one protein at a time?

Laura: Maybe.

Ron: Where is the flagellum?

Laura: I pricked them like propellers on in my head.

Laura: It's a bubble.

Ron: What is?

Laura: What.

Ron: The Flagellum is on the outside of the cell.

Ron: It's for propelling the cell around.

Laura: Oh, a whole cell.

Laura: Oh, crikey.

Ron: Yeah.

Ron: Not the wheelbarrow.

Ron: Bubble.

Laura: Well, maybe the cell is the bubble, then.

Laura: God, there's ink everywhere.

Ron: Anyway.

Ron: My point is, is that all of the processes going on in a cell are very varied.

Ron: Right?

Laura: Yeah.

Ron: Homeostasis is the optimal conditions for all of that stuff to go on at once.

Ron: Right.

Ron: That might differ in different locations in the cell, but it would be things like, as you say, making sure that the temperature is correct, because if it's too cold, things are going to happen too slowly.

Ron: If it's too hot, things are going to start breaking.

Ron: Making sure that the PH level is right.

Ron: Making sure that the salt concentration isn't too high, because then that's going to start sucking water out of things, making sure that the glucose concentration is good, because then you've got enough energy to do the things that you need to do it's kind of monitoring all of that stuff.

Ron: Yeah.

Laura: Okay, cool.

Ron: There's two different types of responses to that can help us balance these things out.

Ron: We've mentioned both of them, one of which is the nervous responses.

Laura: Oh, no.

Ron: And the other one's?

Ron: Chemical responses.

Ron: Nervous responses.

Ron: Electrical signals, like we said before, chemical responses.

Ron: Hormones.

Ron: Can you name any hormones?

Laura: Dopamine?

Ron: Yes, I think.

Ron: Any others?

Laura: Serotonin.

Laura: Adrenaline.

Ron: Very good.

Ron: Any others?

Laura: What's?

Laura: Testosterone?

Ron: Yes.

Ron: What's the lady version of that?

Laura: Oestrogen.

Ron: Absolutely.

Ron: Yeah.

Ron: Very good.

Ron: Control systems will have different parts to them, basically, right?

Ron: Yeah.

Ron: So they will have receptors which do what?

Laura: Receive signals yes.

Ron: That monitor the changes in the environment.

Ron: They will have coordination centres that basically receive that signal, work out how to process it, and then they'll have effectors, which will bring about the responses that will bring us back to homeostasis.

Ron: Yeah.

Laura: Hang on.

Laura: My pen has stopped working just as I'm making the best notes of my life.

Laura: Oh, don't stop working now.

Laura: No.

Laura: Coordination centre.

Laura: And then what was it?

Laura: Reaction stations.

Ron: Effectors.

Laura: Effectors.

Laura: Oh, I'm really annoyed.

Laura: My pen stopped working.

Laura: And these notes were really epic.

Ron: So we're going to do a quick example of one of these control systems.

Ron: Okay.

Laura: Okay.

Ron: So we're going to learn a little bit about how your blood sugar is regulated.

Ron: Okay.

Laura: Blood sugar.

Laura: How come you dance so good?

Ron: Very nice.

Ron: Do you know any of the key players in this?

Laura: Insulin.

Ron: Very good.

Ron: Do you know what the opposite of insulin is?

Laura: Outsulin.

Ron: That's a lovely bit of business.

Laura: Shake.

Laura: It all about ceiling.

Ron: Coke.

Ron: Cecilian.

Ron: No.

Ron: Okay, so blood sugar.

Ron: There are basically three states you could be in, one of which being homeostasis, where we want what are the other ones?

Laura: Hypostasis.

Ron: Hypoglycemia.

Ron: What does that mean?

Laura: Too much sugar.

Ron: Hypoglycemia, I think you said.

Laura: Oh, not enough.

Ron: Yeah.

Ron: And then hyperglycemia, which is too much.

Ron: Exactly.

Ron: Which one do you want to do first?

Laura: Hyper.

Ron: Hyperglycemia, okay.

Ron: How do we achieve hyperglycemia?

Ron: How does that happen?

Laura: Too much glucose, not enough insulin.

Ron: Well, where do we get the glucose from?

Laura: Food.

Ron: Exactly.

Ron: We eat a big sugary meal.

Ron: Child of the podcast Kicking off in the background.

Laura: She is, yeah.

Ron: We eat a big sugary meal.

Ron: First thing that happens, receptors in the pancreas detect all this sugar.

Ron: Okay.

Laura: Yeah.

Ron: They go, Holy s***, there's a lot of sugar in this blood.

Ron: They release the insulin.

Laura: Okay.

Ron: Type two diabetes, I believe, is basically you've had so much sugar in your blood for so long that those cells you're basically the little boy that cried sugar, and those cells start going, don't believe you anymore.

Ron: That's just normal and fine, you stop producing the insulin.

Ron: I think we'll probably do diabetes later.

Ron: This might even be the next bit.

Ron: Hang let me scroll.

Laura: It would be so good if you'd scrolled.

Laura: Pre lesson.

Ron: Shut up.

Ron: Oh, yeah.

Ron: This is a bit that's going to come up later on.

Laura: This is why you're never going to get tenure.

Ron: Shut up.

Ron: Okay, so we'll bruise through this because we'll cover this in more detail later on.

Ron: Pancreas releases insulin into the body.

Ron: The insulin goes to all of your cells and say, hey, chow down.

Ron: Glucose is here specifically, it also goes to the liver.

Laura: So, hang on, does insulin absorb glucose or?

Laura: The insulin tells the cells to use up glucose more?

Ron: The insulin tells your cells to take in the glucose okay.

Ron: To decrease the blood sugar level.

Ron: It also tells your liver to take in the glucose and then it stores it as glycogen.

Laura: Okay.

Ron: Do you remember what glycogen is?

Laura: Sounds flammable.

Laura: Tells liver to store no, I don't know what it is.

Ron: Glycogen is kind of like man starch, human starch.

Laura: Oh, okay.

Ron: It's us storing sugar.

Ron: Yeah.

Ron: Both of these things decrease the amount of blood sugar, blood glucose in levels, it goes down.

Laura: Okay.

Ron: The opposite would be sorry, yawning, your blood glucose has gone too low.

Laura: Yes.

Ron: Again, pancreas.

Ron: This time, alpha cells, they release, this time a hormone called glucagon.

Ron: Nothing for glucagon.

Laura: This sounds trickoey.

Laura: This sounds like we're going to do the quiz for this and you're going to be like I literally called it glucagon.

Laura: Like, get rid of glucose.

Laura: Ha.

Laura: How could you fall for it?

Laura: You deserve everything you get.

Ron: But miraculously, no tricko.

Laura: You wouldn't tell me yet anyway, even if it was.

Ron: Oh, I'm always very open about it.

Ron: If you call my trichos out.

Ron: Okay, it's not a tricko.

Ron: Glucagon.

Ron: Glucagon goes to can you guess where it goes to?

Laura: What are we doing?

Laura: So this is there's not enough sugar.

Ron: Yeah.

Laura: Goes to your where have we just.

Ron: Learnt is storing some sugar?

Laura: Liver.

Laura: It goes to the liver and gets out glycogen.

Ron: Yeah.

Ron: Tells the liver to break down glycogen.

Ron: Very good, Laura.

Ron: The liver then releases that into the bloodstream.

Ron: Homeostasis achieved.

Laura: Nice, lovely stuff.

Laura: I reckon my body right now is releasing insulin because I ate five biscuits before we recorded.

Ron: Probably is, yeah.

Ron: Are there any other control systems like that that you're aware of?

Laura: So I'm too hot and my brain tells my skin to push water out.

Ron: Yeah.

Laura: And then the sweat evaporates and I cool down.

Ron: Yeah.

Ron: Very nice.

Ron: Yeah.

Ron: So there's lots of these and then you get different types of loops and then you get positive feedback loops, negative feedback loops and whatnot.

Ron: Lots of them are interlinked, so you have nervous stuff feeding into chemical stuff.

Ron: That was just one cheeky example.

Ron: How long have we been recording, Lauren?

Laura: 37 minutes.

Ron: That's probably spot on.

Ron: As to the next bit, we're going to be talking about the nervous system in depth, so don't really want to get into that.

Laura: All right.

Laura: Anything else you want to bring up?

Laura: Have a little AGM?

Ron: Well, should we look into how we can twitch stream?

Laura: Watch us now in the recording?

Laura: No, I don't think we should.

Ron: Okay.

Ron: Anything else you want to bring up?

Laura: No, don't think so.

Laura: What are you doing tonight?

Ron: Don't know.

Ron: What are you doing tonight?

Laura: Don't know.

Laura: Because I thought we were recording.

Laura: I don't have any plans.

Ron: We are recording.

Laura: Yeah, but I thought we were doing it.

Laura: Oh, I didn't make any other plans, so probably watch the block with Tom.

Ron: That sounds nice.

Laura: Could play minecraft with you and Meg.

Laura: Yeah, Mabes might walk the dog if it stays dry.

Ron: Yeah, I might go see one of my housemates play some music, but I also might not.

Laura: Listeners, let us know what you're doing tonight.

Laura: It's currently the 19 September, so you need to let us know what we're doing.

Laura: What you were doing that night.

Laura: Not the night you're listening to this.

Laura: All right, lads, see you for the quiz.

Laura: Recording in record time.

Ron: Wow.

Ron: Hi.

Ron: Hello.

Laura: Hi.

Laura: Ron.

Laura: We're doing a quiz.

Laura: No time.

Laura: Lunch break.

Laura: Go monomer.

Ron: Hang on, I haven't even sent you the bloody Google meet yet.

Laura: Metabolism enzymes.

Laura: Imagine all the ding sound effects popping off all over the place right now.

Ron: Ron enzyme arunies.

Ron: There we go.

Laura: This is such an exciting change to our format.

Ron: What, being unprepared and rushed?

Ron: Yeah.

Ron: The listeners have never heard that before.

Laura: Laura he's got the sunglasses back on even though it's a rain episode.

Ron: Bit of extra pep.

Laura: You shut the window so we can't hear the rain as well now.

Laura: But just now.

Laura: Oh, it was full rain situation.

Ron: Laura for three points.

Laura: I love rain episodes.

Laura: They make me nostalgic for the original days.

Laura: For three points.

Ron: Yes, for three points.

Ron: What is homeostasis?

Laura: Homeostasis is the condition of the body when it is in its optimal working conditions.

Laura: It's the regulation of the body.

Ron: You're at two out of three so far.

Ron: There's, like an extra side to it.

Laura: And it is all about all of your organelles and enzymes functioning together and.

Ron: Adapting their processes to kind of bracketed under optimal conditions.

Laura: Okay, it's healthy.

Ron: There's no mark for it.

Ron: Healthy.

Ron: Why do we need to regulate now.

Laura: You can hear the rain.

Laura: What do you mean?

Laura: Why do we need to.

Laura: Regulate to stay healthy, to stay in our tip top condition.

Ron: Yeah.

Ron: So like you've said, to maintain optimal conditions.

Ron: Yeah, we've done that.

Laura: Things get out of sync.

Ron: How?

Laura: Like too much glucose or oh, no, too hard.

Ron: Summarise that senor.

Laura: Bad things happen to people.

Ron: All right?

Ron: You're not getting it.

Ron: In response to internal and external changes is the third bit.

Ron: I'll give you half a mark.

Laura: Give me the full d*** mark.

Ron: I won't.

Laura: All right.

Laura: I don't care that much.

Laura: I know, I know it.

Ron: Could you please three conditions that it covers that we discussed in the bulk of the episode.

Laura: Blood sugar, temperature, body temperature and and too much salt.

Laura: Salt level.

Laura: I remember we discussed temperature and we discussed high blood sugar and low blood sugar.

Ron: Yeah.

Ron: Blood sugar, saltiness.

Laura: Yeah.

Ron: Is that part of it?

Laura: Yeah.

Ron: Sodium regulation?

Ron: That is part of it.

Ron: Good job, Laura.

Ron: Well done.

Laura: Woohoo.

Ron: Another three marks, bringing you to a total of five, six and a half marks.

Ron: Okay, Laura.

Laura: Yes.

Laura: Final question ever in Lex education.

Ron: This is the last episode of Lex Education.

Ron: What for six points, please describe the control system for blood sugar.

Laura: Right.

Ron: You got three points for each branch of it.

Laura: Okay, so let's say you got too much sugar in your bloodstream, okay?

Laura: Pancreas gets involved, kicks out insulin.

Laura: Insulin goes around the body into the cells and says, use up glucose.

Laura: Make your priority using up glucose and encourages the cells to process glucose.

Laura: Use it up.

Laura: And then especially, it goes to the liver and it says to the liver, pack away all this glucose.

Laura: Nice and tidy, boys.

Laura: Too much glucose flying around this place.

Laura: What do you think this is, pigs diner?

Laura: Put the glucose into glycogen and the liver stores up the glycogen and the blood sugar levels return to normal.

Laura: Then if you haven't got enough glucose in your blood, the glycagon goes to the liver and goes blood.

Ron: Try again with glycagon.

Ron: You're very close.

Laura: You it's like a.

Ron: Get, it's almost glue.

Ron: Close to glucagon.

Laura: Glucagon.

Laura: The glucagon, yeah.

Laura: Glucagon comes out of the alpha cells and they go to the liver and they start unpacking all the glycogen and spreading it back out around the blood.

Laura: And then it's all imbalanced again.

Ron: Five marks out of six, Laura.

Ron: Really good job.

Laura: Why five?

Ron: Because it doesn't tell cells to start processing the glucose more, it tells cells to take in glucose.

Laura: Same thing.

Ron: You did really well.

Ron: You got five out of six.

Laura: I wanted all of them.

Laura: I felt like I was on top of the world.

Ron: You were slightly beneath top of the.

Laura: Ah, all right, well, it's better than where I usually am.

Ron: Yeah.

Ron: Bottom of the world.

Laura: I hope you enjoyed listening to Lex Education.

Laura: That's the end of the podcast forever.

Laura: Goodbye.

Laura: She's a new favourite.

Laura: See you.

Ron: Not next week.

Laura: Never see you again.

Laura: I'm retiring from public life.

Ron: I'm going to go back to doing a normal job.

Laura: You still do your normal job, Ron.

Ron: I don't work as hard as I used to.

Laura: I don't think that's going to change with the end of the podcast.

Laura: I don't think it's the podcast that's distracting you.

Laura: No, I think it's the sweet, sweet Bristol nightlives that I spend playing minecraft aliens at your friend's house.

Laura: And my husband.

Ron: Yeah.

Ron: It's nice chatting with husband at the podcast time yesterday.

Laura: He's the nicest man in the world.

Laura: I've been saying it for a long time.

Laura: Huge.

Ron: He's a nice boy.

Ron: He's also not always nice.

Laura: No, but that's what makes him nice, I think.

Laura: He's not sappy.

Laura: Yeah, just great.

Ron: He's a bit rude, a bit rough sometimes.

Ron: Bit of a rude dude.

Laura: I like it.

Ron: All right, no more Pegging channel attended.

Ron: Cool beans.

Ron: Right, okay.

Ron: That was an episode, wasn't it?

Ron: We all loved it homeostasis.

Ron: It was good, I just listened to it.

Ron: But I've got such a bloody flu fog in my brain that I can't say loads for it.

Ron: Yeah.

Ron: Just quite cooperative.

Ron: A bit of rain biology stuff.

Ron: It was all good, really.

Ron: Now, I'm not going to subject you to this for too long.

Ron: Laura said on Twitter or something that we would redo the sullen patreon register from last week.

Ron: I'm not going to do that.

Ron: I didn't f*** it up the first time.

Ron: I don't think that's on me to repay a debt to someone that I haven't wronged.

Ron: I spent ages writing those patreon register things, only for Laura to fritter it down the toilet.

Ron: So I'm going to do some new ones and then next week she's going to do a grovelling apology, because I don't think it would sit right to the good people that were scorned last week if the retribution that they received wasn't even from Laura.

Ron: So drum rolls and fanfare pinwheels and children's laughter please, for the patreon register.

Ron: First up, we'd like to say a huge thank you to Sandra, who will be playing Juliet in the Holo production of Hand Juliet, straight from their sellout run as the titular character in the hottest play.

Ron: Then I'd like to say a big, massive Lex education thank you to Christine Ellis.

Ron: Christine is the tattoo artist that has to follow Laura around at all times while she lives in her Memento like existence, stumbling around and saying amino acid at people, hoping that one day it will finally have been the right and timely thing to say.

Ron: And finally, for this week, a huge thank you to Mash, who is cats nine and ten.

Ron: Lovely stuff.

Ron: What else am I supposed to do?

Ron: There weren't many alternative names for the podcast last week because I kind of flown that in.

Ron: So all car is what last week's episode was called.

Ron: Then I had rice is bitty.

Ron: Curry is soft.

Ron: You don't have to get the punctuation completely correct.

Ron: Yes, I can semicolon watch me fly and I can hear your mouth, too.

Ron: So if you got any of them, give yourself a gold star.

Ron: Further than that, just have a nice week.

Ron: Wish me well.

Ron: I'm ill wish Laura better time management next week, I guess.

Ron: It won't be her birthday next week, so she'll probably be fine.

Ron: And further than that, just look after yourselves, guys.

Ron: Scary world out there, and we wouldn't want anything happening to you.

Ron: So first time without being prompted, because there's no one here to prompt me.

Ron: Class dismissed.